Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation : Findings From the Pregnancy and Childhood Epigenetics Consortium

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dc.contributor.author Howe, Caitlin G.
dc.contributor.author Cox, Bianca
dc.contributor.author Fore, Ruby
dc.contributor.author Jungius, James
dc.contributor.author Kvist, Tuomas
dc.contributor.author Lent, Samantha
dc.contributor.author Miles, Harriet E.
dc.contributor.author Salas, Lucas A.
dc.contributor.author Rifas-Shiman, Sheryl
dc.contributor.author Starling, Anne P.
dc.contributor.author Yousefi, Paul
dc.contributor.author Ladd-Acosta, Christine
dc.contributor.author Baccarelli, Andrea
dc.contributor.author Binder, Elisabeth B.
dc.contributor.author Chatzi, Vaia Lida
dc.contributor.author Czamara, Darina
dc.contributor.author Dabelea, Dana
dc.contributor.author DeMeo, Dawn L.
dc.contributor.author Ghantous, Akram
dc.contributor.author Herceg, Zdenko
dc.contributor.author Kajantie, Eero
dc.contributor.author Lahti, Jari M. T.
dc.contributor.author Lawlor, Debbie A.
dc.contributor.author Litonjua, Augusto
dc.contributor.author Nawrot, Tim S.
dc.contributor.author Nohr, Ellen A.
dc.contributor.author Oken, Emily
dc.contributor.author Pizzi, Costanza
dc.contributor.author Plusquin, Michelle
dc.contributor.author Räikkönen, Katri
dc.contributor.author Relton, Caroline L.
dc.contributor.author Sharp, Gemma C.
dc.contributor.author Sorensen, Thorkild I. A.
dc.contributor.author Sunyer, Jordi
dc.contributor.author Vrijheid, Martine
dc.contributor.author Zhang, Weiming
dc.contributor.author Hivert, Marie-France
dc.contributor.author Breton, Carrie V.
dc.date.accessioned 2021-03-08T22:54:46Z
dc.date.available 2021-03-08T22:54:46Z
dc.date.issued 2020-01
dc.identifier.citation Howe , C G , Cox , B , Fore , R , Jungius , J , Kvist , T , Lent , S , Miles , H E , Salas , L A , Rifas-Shiman , S , Starling , A P , Yousefi , P , Ladd-Acosta , C , Baccarelli , A , Binder , E B , Chatzi , V L , Czamara , D , Dabelea , D , DeMeo , D L , Ghantous , A , Herceg , Z , Kajantie , E , Lahti , J M T , Lawlor , D A , Litonjua , A , Nawrot , T S , Nohr , E A , Oken , E , Pizzi , C , Plusquin , M , Räikkönen , K , Relton , C L , Sharp , G C , Sorensen , T I A , Sunyer , J , Vrijheid , M , Zhang , W , Hivert , M-F & Breton , C V 2020 , ' Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation : Findings From the Pregnancy and Childhood Epigenetics Consortium ' , Diabetes Care , vol. 43 , no. 1 , pp. 98-105 . https://doi.org/10.2337/dc19-0524
dc.identifier.other PURE: 131789424
dc.identifier.other PURE UUID: 375d7527-7eab-42af-aa3b-f02015f2f2a2
dc.identifier.other WOS: 000508573600025
dc.identifier.other ORCID: /0000-0002-4310-5297/work/70941824
dc.identifier.other ORCID: /0000-0003-3124-3470/work/70946841
dc.identifier.uri http://hdl.handle.net/10138/327661
dc.description.abstract OBJECTIVE Maternal gestational diabetes mellitus (GDM) has been associated with adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play a role, but most previous studies have been small and adjusted for few covariates. The current study meta-analyzed the association between maternal GDM and cord blood DNA methylation in the Pregnancy and Childhood Epigenetics (PACE) consortium. RESEARCH DESIGN AND METHODS Seven pregnancy cohorts (3,677 mother-newborn pairs [317 with GDM]) contributed results from epigenome-wide association studies, using DNA methylation data acquired by the Infinium HumanMethylation450 BeadChip array. Associations between GDM and DNA methylation were examined using robust linear regression, with adjustment for potential confounders. Fixed-effects meta-analyses were performed using METAL. Differentially methylated regions (DMRs) were identified by taking the intersection of results obtained using two regional approaches: comb-p and DMRcate. RESULTS Two DMRs were identified by both comb-p and DMRcate. Both regions were hypomethylated in newborns exposed to GDM in utero compared with control subjects. One DMR (chr 1: 248100345-248100614) was located in the OR2L13 promoter, and the other (chr 10: 135341870-135342620) was located in the gene body of CYP2E1. Individual CpG analyses did not reveal any differentially methylated loci based on a false discovery rate-adjusted P value threshold of 0.05. CONCLUSIONS Maternal GDM was associated with lower cord blood methylation levels within two regions, including the promoter of OR2L13, a gene associated with autism spectrum disorder, and the gene body of CYP2E1, which is upregulated in type 1 and type 2 diabetes. Future studies are needed to understand whether these associations are causal and possible health consequences. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Diabetes Care
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject CORD BLOOD
dc.subject ASSOCIATION
dc.subject GENES
dc.subject CLASSIFICATION
dc.subject HYPERGLYCEMIA
dc.subject DIAGNOSIS
dc.subject CRITERIA
dc.subject 3111 Biomedicine
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation : Findings From the Pregnancy and Childhood Epigenetics Consortium en
dc.type Article
dc.contributor.organization Department of Psychology and Logopedics
dc.contributor.organization Developmental Psychology Research Group
dc.contributor.organization University of Helsinki
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Clinicum
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Children's Hospital
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.2337/dc19-0524
dc.relation.issn 0149-5992
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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