Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression : Role of MAPK signaling pathway

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http://hdl.handle.net/10138/327666

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Humo , M , Ayazgok , B , Becker , L J , Waltisperger , E , Rantamäki , T & Yalcin , I 2020 , ' Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression : Role of MAPK signaling pathway ' , Progress in Neuro-Psychopharmacology & Biological Psychiatry , vol. 100 , 109898 . https://doi.org/10.1016/j.pnpbp.2020.109898

Title: Ketamine induces rapid and sustained antidepressant-like effects in chronic pain induced depression : Role of MAPK signaling pathway
Author: Humo, Muris; Ayazgok, Beyza; Becker, Lea J.; Waltisperger, Elisabeth; Rantamäki, Tomi; Yalcin, Ipek
Contributor: University of Helsinki, Drug Research Program
Date: 2020-06-08
Language: eng
Number of pages: 8
Belongs to series: Progress in Neuro-Psychopharmacology & Biological Psychiatry
ISSN: 0278-5846
URI: http://hdl.handle.net/10138/327666
Abstract: Chronic pain produces psychologic distress, which often leads to mood disorders such as depression. Co-existing chronic pain and depression pose a serious socio-economic burden and result in disability affecting millions of individuals, which urges the development of treatment strategies targeting this comorbidity. Ketamine, a noncompetitive antagonist of the N-methyl-d-aspartate (NMDA) receptor, is shown to be efficient in treating both pain and depression-related symptoms. However, the molecular characteristics of its role in chronic pain-induced depression remain largely unexplored. Hence, we studied the behavioral and molecular effects of a single systemic administration of ketamine (15 mg/kg, i.p.) on mechanical hypersensitivity and depressive-like consequences of chronic neuropathic pain. We showed that ketamine transiently alleviated mechanical hypersensitivity (lasting
Subject: Ketamine
Neuropathic pain-induced depression
Comorbidity
Anterior cingulate cortex
MKP-1
pERK
ANTERIOR CINGULATE CORTEX
PROTEIN-KINASE PHOSPHATASE-1
NMDA RECEPTOR BLOCKADE
NEUROPATHIC PAIN
PHARMACOLOGICAL-TREATMENT
RAT MODEL
ACTIVATION
MECHANISMS
EXPRESSION
BEHAVIORS
3112 Neurosciences
317 Pharmacy
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