Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity

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Lahelma , M , Luukkonen , P K , Qadri , S , Ahlholm , N , Lallukka-Brück , S , Porthan , K , Juuti , A , Sammalkorpi , H , Penttilä , A K , Arola , J , Orho-Melander , M & Yki-Järvinen , H 2021 , ' Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity ' , Nutrients , vol. 13 , no. 1 , 169 . https://doi.org/10.3390/nu13010169

Title: Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity
Author: Lahelma, Mari; Luukkonen, Panu K.; Qadri, Sami; Ahlholm, Noora; Lallukka-Brück, Susanna; Porthan, Kimmo; Juuti, Anne; Sammalkorpi, Henna; Penttilä, Anne K.; Arola, Johanna; Orho-Melander, Marju; Yki-Järvinen, Hannele
Contributor: University of Helsinki, Department of Medicine
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Doctoral Programme in Clinical Research
University of Helsinki, Clinicum
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Kardiologian yksikkö
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUSLAB
University of Helsinki, Department of Medicine
Date: 2021-01
Language: eng
Number of pages: 13
Belongs to series: Nutrients
ISSN: 2072-6643
URI: http://hdl.handle.net/10138/327751
Abstract: Only some individuals with obesity develop liver fibrosis due to non-alcoholic fatty liver disease (NAFLD-fibrosis). We determined whether detailed assessment of lifestyle factors in addition to physical, biochemical and genetic factors helps in identification of these patients. A total of 100 patients with obesity (mean BMI 40.0 +/- 0.6 kg/m(2)) referred for bariatric surgery at the Helsinki University Hospital underwent a liver biopsy to evaluate liver histology. Physical activity was determined by accelerometer recordings and by the Modifiable Activity Questionnaire, diet by the FINRISK Food Frequency Questionnaire, and other lifestyle factors, such as sleep patterns and smoking, by face-to-face interviews. Physical and biochemical parameters and genetic risk score (GRS based on variants in PNPLA3, TM6SF2, MBOAT7 and HSD17B13) were measured. Of all participants 49% had NAFLD-fibrosis. Independent predictors of NAFLD-fibrosis were low moderate-to-vigorous physical activity, high red meat intake, low carbohydrate intake, smoking, HbA(1c), triglycerides and GRS. A model including these factors (areas under the receiver operating characteristics curve (AUROC) 0.90 (95% CI 0.84-0.96)) identified NAFLD-fibrosis significantly more accurately than a model including all but lifestyle factors (AUROC 0.82 (95% CI 0.73-0.91)) or models including lifestyle, physical and biochemical, or genetic factors alone. Assessment of lifestyle parameters in addition to physical, biochemical and genetic factors helps to identify obese patients with NAFLD-fibrosis.
Subject: physical activity
diet
stress
glucose
insulin
3143 Nutrition
3121 General medicine, internal medicine and other clinical medicine
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