Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity

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Lahelma , M , Luukkonen , P K , Qadri , S , Ahlholm , N , Lallukka-Brück , S , Porthan , K , Juuti , A , Sammalkorpi , H , Penttilä , A K , Arola , J , Orho-Melander , M & Yki-Järvinen , H 2021 , ' Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity ' , Nutrients , vol. 13 , no. 1 , 169 . https://doi.org/10.3390/nu13010169

Title: Assessment of Lifestyle Factors Helps to Identify Liver Fibrosis Due to Non-Alcoholic Fatty Liver Disease in Obesity
Author: Lahelma, Mari; Luukkonen, Panu K.; Qadri, Sami; Ahlholm, Noora; Lallukka-Brück, Susanna; Porthan, Kimmo; Juuti, Anne; Sammalkorpi, Henna; Penttilä, Anne K.; Arola, Johanna; Orho-Melander, Marju; Yki-Järvinen, Hannele
Contributor organization: Department of Medicine
University of Helsinki
Helsinki University Hospital Area
HUS Internal Medicine and Rehabilitation
Doctoral Programme in Clinical Research
Clinicum
Kardiologian yksikkö
HUS Abdominal Center
II kirurgian klinikka
Department of Surgery
HUSLAB
Department of Pathology
Date: 2021-01
Language: eng
Number of pages: 13
Belongs to series: Nutrients
ISSN: 2072-6643
DOI: https://doi.org/10.3390/nu13010169
URI: http://hdl.handle.net/10138/327751
Abstract: Only some individuals with obesity develop liver fibrosis due to non-alcoholic fatty liver disease (NAFLD-fibrosis). We determined whether detailed assessment of lifestyle factors in addition to physical, biochemical and genetic factors helps in identification of these patients. A total of 100 patients with obesity (mean BMI 40.0 +/- 0.6 kg/m(2)) referred for bariatric surgery at the Helsinki University Hospital underwent a liver biopsy to evaluate liver histology. Physical activity was determined by accelerometer recordings and by the Modifiable Activity Questionnaire, diet by the FINRISK Food Frequency Questionnaire, and other lifestyle factors, such as sleep patterns and smoking, by face-to-face interviews. Physical and biochemical parameters and genetic risk score (GRS based on variants in PNPLA3, TM6SF2, MBOAT7 and HSD17B13) were measured. Of all participants 49% had NAFLD-fibrosis. Independent predictors of NAFLD-fibrosis were low moderate-to-vigorous physical activity, high red meat intake, low carbohydrate intake, smoking, HbA(1c), triglycerides and GRS. A model including these factors (areas under the receiver operating characteristics curve (AUROC) 0.90 (95% CI 0.84-0.96)) identified NAFLD-fibrosis significantly more accurately than a model including all but lifestyle factors (AUROC 0.82 (95% CI 0.73-0.91)) or models including lifestyle, physical and biochemical, or genetic factors alone. Assessment of lifestyle parameters in addition to physical, biochemical and genetic factors helps to identify obese patients with NAFLD-fibrosis.
Subject: physical activity
diet
stress
glucose
insulin
3143 Nutrition
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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