Dietary intake and hospitalisation due to diabetic ketoacidosis and hypoglycaemia in individuals with type 1 diabetes

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Ahola , A J , Harjutsalo , V , Thomas , M C , Forsblom , C & Groop , P-H 2021 , ' Dietary intake and hospitalisation due to diabetic ketoacidosis and hypoglycaemia in individuals with type 1 diabetes ' , Scientific Reports , vol. 11 , no. 1 , 1638 . https://doi.org/10.1038/s41598-021-81180-0

Title: Dietary intake and hospitalisation due to diabetic ketoacidosis and hypoglycaemia in individuals with type 1 diabetes
Author: Ahola, Aila J.; Harjutsalo, Valma; Thomas, Merlin C.; Forsblom, Carol; Groop, Per-Henrik
Other contributor: University of Helsinki, Clinicum
University of Helsinki, Research Programs Unit
University of Helsinki, HUS Abdominal Center
University of Helsinki, HUS Abdominal Center









Date: 2021-01-15
Language: eng
Number of pages: 7
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-021-81180-0
URI: http://hdl.handle.net/10138/327756
Abstract: We investigated the association between diet and risk of hospitalisation for diabetic ketoacidosis (DKA) or hypoglycaemia in type 1 diabetes. Food records were used to assess dietary intake. Data on DKA and hypoglycaemia hospitalisations, within two years of dietary assessments, were obtained from registries. Analyses were conducted with and without macronutrient substitution. Data were available from 1391 participants, 28 (2.0%) and 55 (4.0%) of whom were hospitalised due to DKA or hypoglycaemia, respectively. In the adjusted model, self-reported alcohol intake was associated with increased (per 10 g: B=1.463, 95% CI=1.114-1.922, p=0.006; per E%: B=1.113, 95% CI=1.027-1.206, p=0.009), and fibre intake with reduced (per g/MJ: B=0.934, 95% CI=0.878-0.995, p=0.034) risk of DKA hospitalisation. Substituting carbohydrates for fats was associated with increased risk for hypoglycaemia hospitalisation (B=1.361, 95% CI=1.031-1.795, p=0.029), while substituting alcohol for carbohydrates (B=1.644, 95% CI=1.006-2.685, p=0.047) or proteins (B=2.278, 95% CI=1.038-4.999, p=0.040) increased the risk for DKA hospitalisation. In conclusion, refraining from alcohol intake is a preventable risk factor for DKA, while higher fibre intake seems rather protective. Increasing carbohydrate intake while decreasing that of fats, is associated with higher hypoglycaemia risk. Whether this is a cause or effect of hypoglycaemia remains to be established.
Subject: LOW CARBOHYDRATE-DIET
GLYCEMIC CONTROL
RISK
ADOLESCENTS
ADULTS
3121 General medicine, internal medicine and other clinical medicine
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