Janus kinases to jakinibs : from basic insights to clinical practice

Show full item record



Permalink

http://hdl.handle.net/10138/327839

Citation

Gadina , M , Le , M T , Schwartz , D M , Silvennoinen , O , Nakayamada , S , Yamaoka , K & O'Shea , J J 2019 , ' Janus kinases to jakinibs : from basic insights to clinical practice ' , Rheumatology , vol. 58 , pp. 4-16 . https://doi.org/10.1093/rheumatology/key432

Title: Janus kinases to jakinibs : from basic insights to clinical practice
Author: Gadina, Massimo; Le, Mimi T.; Schwartz, Daniella M.; Silvennoinen, Olli; Nakayamada, Shingo; Yamaoka, Kunihiro; O'Shea, John J.
Contributor: University of Helsinki, Institute of Biotechnology
Date: 2019-02
Language: eng
Number of pages: 13
Belongs to series: Rheumatology
ISSN: 1462-0324
URI: http://hdl.handle.net/10138/327839
Abstract: Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting cytokines and cytokine receptors with biologics has revolutionized the treatment of many of these diseases, but targeting intracellular signalling with Janus kinase (JAK) inhibitors (jakinibs) now represents a major new therapeutic advance. We are still in the first decade since these drugs were approved and there is still much to be learned about the mechanisms of action of these drugs and the practical use of these agents. Herein we will review cytokines that do, and just as importantly, do not signal by JAKs, as well as explain how this relates to both efficacy and side effects in various diseases. We will review new, next-generation selective jakinibs, as well as the prospects and challenges ahead in targeting JAKs.
Subject: cytokines
signal transduction
Janus kinases
kinase inhibitors
autoimmunity
inflammation
MODIFYING ANTIRHEUMATIC DRUG
COMBINED IMMUNE-DEFICIENCY
SELECTIVE JAK-1 INHIBITOR
RHEUMATOID-ARTHRITIS
INADEQUATE RESPONSE
TYROSINE KINASE
PRIMARY MYELOFIBROSIS
TRANSCRIPTION FACTORS
VX-509 DECERNOTINIB
DISEASE-ACTIVITY
1182 Biochemistry, cell and molecular biology
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Gadina_et_al_Rh ... us_kinases_to_jakinibs.pdf 936.1Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record