Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity

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Deshmukh , H A , Madsen , A L , Vinuela , A , Have , C T , Grarup , N , Tura , A , Mahajan , A , Heggie , A J , Koivula , R W , De Masi , F , Tsirigos , K K , Linneberg , A , Drivsholm , T , Pedersen , O , Sorensen , T I A , Astrup , A , Gjesing , A A P , Pavo , I , Wood , A R , Ruetten , H , Jones , A G , Koopman , A D M , Cederberg , H , Rutters , F , Ridderstrale , M , Laakso , M , McCarthy , M , Frayling , T M , Ferrannini , E , Franks , P W , Pearson , E R , Mari , A , Hansen , T & Walker , M 2021 , ' Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity ' , Journal of Clinical Endocrinology and Metabolism , vol. 106 , no. 1 , pp. 80-90 .

Title: Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity
Author: Deshmukh, Harshal A.; Madsen, Anne Lundager; Vinuela, Ana; Have, Christian Theil; Grarup, Niels; Tura, Andrea; Mahajan, Anubha; Heggie, Alison J.; Koivula, Robert W.; De Masi, Federico; Tsirigos, Konstantinos K.; Linneberg, Allan; Drivsholm, Thomas; Pedersen, Oluf; Sorensen, Thorkild I. A.; Astrup, Arne; Gjesing, Anette A. P.; Pavo, Imre; Wood, Andrew R.; Ruetten, Hartmut; Jones, Angus G.; Koopman, Anitra D. M.; Cederberg, Henna; Rutters, Femke; Ridderstrale, Martin; Laakso, Markku; McCarthy, Mark; Frayling, Tim M.; Ferrannini, Ele; Franks, Paul W.; Pearson, Ewan R.; Mari, Andrea; Hansen, Torben; Walker, Mark
Contributor organization: HUS Abdominal Center
Department of Medicine
Endokrinologian yksikkö
Helsinki University Hospital Area
Date: 2021-01
Language: eng
Number of pages: 11
Belongs to series: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021-972X
Abstract: Context: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity. Objective: To understand the genetic determinants of pancreatic beta-cell glucose sensitivity using genome-wide meta-analysis and candidate gene studies. Design: We performed a genome-wide meta-analysis for beta-cell glucose sensitivity in subjects with type 2 diabetes and nondiabetic subjects from 6 independent cohorts (n = 5706). Beta-cell glucose sensitivity was calculated from mixed meal and oral glucose tolerance tests, and its associations between known glycemia-related single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) SNPs were estimated using linear regression models. Results: Beta-cell glucose sensitivity was moderately heritable (h2 ranged from 34% to 55%) using SNP and family-based analyses. GWAS meta-analysis identified multiple correlated SNPs in the CDKAL1 gene and GIPR-QPCTL gene loci that reached genome-wide significance, with SNP rs2238691 in GIPR-QPCTL (P value = 2.64 x 10(-9)) and rs9368219 in the CDKAL1 (P value = 3.15 x 10(-9)) showing the strongest association with beta-cell glucose sensitivity. These loci surpassed genome-wide significance when the GWAS meta-analysis was repeated after exclusion of the diabetic subjects. After correction for multiple testing, glycemia-associated SNPs in or near the HHEX and IGF2B2 loci were also associated with beta-cell glucose sensitivity. Conclusion: We show that, variation at the GIPR-QPCTL and CDKAL1 loci are key determinants of pancreatic beta-cell glucose sensitivity.
Subject: Glucose intolerance
diabetes progression
beta-cell function
mathematical model
RS7754840 G/C
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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