Depression Is Associated With Progression of Diabetic Nephropathy in Type 1 Diabetes

Show full item record



FinnDiane Study Grp , Ahola , A J , Harjutsalo , V , Forsblom , C , Pouwer , F & Groop , P-H 2021 , ' Depression Is Associated With Progression of Diabetic Nephropathy in Type 1 Diabetes ' , Diabetes Care , vol. 44 , no. 1 , pp. 174-180 .

Title: Depression Is Associated With Progression of Diabetic Nephropathy in Type 1 Diabetes
Author: FinnDiane Study Grp; Ahola, Aila J.; Harjutsalo, Valma; Forsblom, Carol; Pouwer, Francois; Groop, Per-Henrik
Contributor organization: HUS Abdominal Center
Nefrologian yksikkö
University of Helsinki
Helsinki University Hospital Area
CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
Research Programs Unit
Department of Medicine
Per Henrik Groop / Principal Investigator
Date: 2021-01
Language: eng
Number of pages: 7
Belongs to series: Diabetes Care
ISSN: 0149-5992
Abstract: OBJECTIVE To investigate the relationship between depression and diabetic nephropathy progression in type 1 diabetes. RESEARCH DESIGN AND METHODS Data from 3,730 participants without end-stage renal disease (ESRD) at baseline, participating in the Finnish Diabetic Nephropathy Study, were included. Depression was assessed in three ways. Depression diagnoses were obtained from the Finnish Care Register for Health Care. Antidepressant agent purchase data were obtained from the Drug Prescription Register. Symptoms of depression were assessed using the Beck Depression Inventory (BDI). Based on their urinary albumin excretion rate (AER), participants were classified as those with normal AER, microalbuminuria, and macroalbuminuria. Progression from normal AER to microalbuminuria, macroalbuminuria, or ESRD; from microalbuminuria to macroalbuminuria or ESRD; or from macroalbuminuria to ESRD, during the follow-up period, was investigated. RESULTS Over a mean follow-up period of 9.6 years, renal status deteriorated in 18.4% of the participants. Diagnosed depression and antidepressant purchases before baseline were associated with 53% and 32% increased risk of diabetic nephropathy progression, respectively. Diagnosed depression assessed during follow-up remained associated with increased risk of disease progression (32%). BDI-derived symptoms of depression showed no association with the progression, but the total number of antidepressant purchases modestly reduced the risk (hazard ratio 0.989 [95% CI 0.982-0.997]), P = 0.008). With the sample divided based on median age, the observations followed those seen in the whole group. However, symptoms of depression additionally predicted progression in those age
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
Depression_is_a ... thy_in_type_1_diabetes.pdf 375.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record