Trigeminal neuralgia in multiple sclerosis: prevalence and association with demyelination

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Laakso , S M , Hekali , O , Kurdo , G , Martola , J , Sairanen , T & Atula , S 2020 , ' Trigeminal neuralgia in multiple sclerosis: prevalence and association with demyelination ' , Acta Neurologica Scandinavica , vol. 142 , no. 2 , pp. 139-144 . https://doi.org/10.1111/ane.13243

Title: Trigeminal neuralgia in multiple sclerosis: prevalence and association with demyelination
Author: Laakso, Sini M; Hekali, Oskari; Kurdo, Goran; Martola, Juha; Sairanen, Tiina; Atula, Sari
Contributor organization: TRIMM - Translational Immunology Research Program
HUS Neurocenter
Department of Neurosciences
Helsinki University Hospital Area
Neurologian yksikkö
Department of Diagnostics and Therapeutics
HUS Medical Imaging Center
Clinicum
University of Helsinki
Date: 2020-08
Language: eng
Number of pages: 6
Belongs to series: Acta Neurologica Scandinavica
ISSN: 0001-6314
DOI: https://doi.org/10.1111/ane.13243
URI: http://hdl.handle.net/10138/328170
Abstract: Objectives The association of trigeminal neuralgia (TN) with multiple sclerosis (MS) is still widely unaddressed in larger, systematical clinical series. In this study, a cohort of Finnish MS patients was assessed regarding the incidence and prevalence of TN, as well as the presence of demyelinating lesions near the trigeminal ganglion, thus searching for a causative role of MS plaques in TN onset. Materials & Methods All consecutive patients treated and followed up for MS (ICD-code G35) in Helsinki University Hospital during 2004-2017 were identified from the Finnish MS register. A hospital administrative database search was used to identify all patients treated and followed up for TN during the same period. Among the MS patients, head MRI scans available from the diagnostic phase of TN or thereafter were analysed. Results We identified a total of 2575 patients with MS and 2008 patients with TN. Both diagnoses could be verified for 55 patients, giving a prevalence of 2.1% for TN in MS. The incidence of TN in MS patients was 149/100 000 person-years (95% CI 108-190). In the general outpatient population of our neurological department, the incidence of TN was 9.9/100 000 person-years (95% CI 9.5-10.3). A demyelinating lesion in the proximity of the trigeminal ganglia was seen for 63% of the 41 patients with relevant MRI data available. Conclusions Incidence of TN among MS patients was 15-fold higher than in the general neurological outpatient population, thus in favour of a strong association between MS and TN.
Subject: 3112 Neurosciences
Multiple Sclerosis
Neuroimaging
Trigeminal neuralgia
POPULATION
PAIN
HEADACHE
multiple sclerosis
trigeminal neuralgia
neuroimaging
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: acceptedVersion


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