Maternal antenatal stress and mental and behavioral disorders in their children

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http://hdl.handle.net/10138/328200

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Tuovinen , S , Lahti-Pulkkinen , M , Girchenko , P , Heinonen , K , Lahti , J , Reynolds , R M , Hamalainen , E , Villa , P M , Kajantie , E , Laivuori , H & Raikkonen , K 2021 , ' Maternal antenatal stress and mental and behavioral disorders in their children ' , Journal of Affective Disorders , vol. 278 , pp. 57-65 . https://doi.org/10.1016/j.jad.2020.09.063

Title: Maternal antenatal stress and mental and behavioral disorders in their children
Author: Tuovinen, Soile; Lahti-Pulkkinen, Marius; Girchenko, Polina; Heinonen, Kati; Lahti, Jari; Reynolds, Rebecca M.; Hamalainen, Esa; Villa, Pia M.; Kajantie, Eero; Laivuori, Hannele; Raikkonen, Katri
Other contributor: University of Helsinki, Medicum
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Medicum
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Medicum
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Gynecology and Obstetrics
University of Helsinki, Department of Psychology and Logopedics













Date: 2021-01-01
Language: eng
Number of pages: 9
Belongs to series: Journal of Affective Disorders
ISSN: 0165-0327
DOI: https://doi.org/10.1016/j.jad.2020.09.063
URI: http://hdl.handle.net/10138/328200
Abstract: Background: Maternal antenatal stress, including symptoms of depression, anxiety and perceived stress, is associated with mental and behavioral problems in children. Whether it is associated with child mental and behavioral disorders remains uncertain. We examined if maternal antenatal symptoms of depression, anxiety and perceived stress were associated with mental and behavioral disorders in their children, if the associations varied according to gestational week, stress type, fluctuating or consistently high symptoms, and if they were driven by maternal or paternal lifetime mood or anxiety disorders. Methods: 3365 mothers participating in the Prediction and Prevention of Preeclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiologic Studies Depression Scale, the State Anxiety Inventory and the Perceived Stress Scale up to 14 times throughout pregnancy. The Care Register for Health Care provided data on mental and behavioral (including neurodevelopmental) disorders for their children from birth (11/07/2006-07/24/2010) until 12/31/2016 and for parental lifetime mood and anxiety disorders until 12/31/ 2016. Results: The hazard of any childhood mental and behavioral disorder (HR=1.91, 95% CI: 1.39-2.51) was significantly higher for children whose mothers reported consistently high in comparison to consistently low levels of all types of stress throughout pregnancy. The associations remained significant when adjusted for maternal and paternal lifetime mood and anxiety disorders (and their comorbidity and timing and mood disorder type). Conclusion: Maternal antenatal stress is associated with higher risk of childhood mental and behavioral disorders. Efforts to reduce maternal antenatal stress should be given a high priority to improve child mental health.
Subject: Fetal programming
Mental disorders
Prenatal stress
Depression
Anxiety
DEPRESSIVE SYMPTOMS
PRENATAL STRESS
EARLY-PREGNANCY
BIRTH-WEIGHT
ANXIETY
RISK
ASSOCIATIONS
METAANALYSIS
MOOD
AGE
515 Psychology
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