Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study

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Oikarinen , M , Puustinen , L , Lehtonen , J , Hakola , L , Simell , S , Toppari , J , Ilonen , J , Veijola , R , Virtanen , S M , Knip , M & Hyöty , H 2021 , ' Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study ' , Frontiers in Immunology , vol. 11 , 604529 . https://doi.org/10.3389/fimmu.2020.604529

Title: Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
Author: Oikarinen, Maarit; Puustinen, Leena; Lehtonen, Jussi; Hakola, Leena; Simell, Satu; Toppari, Jorma; Ilonen, Jorma; Veijola, Riitta; Virtanen, Suvi M.; Knip, Mikael; Hyöty, Heikki
Contributor organization: HUS Children and Adolescents
Children's Hospital
University of Helsinki
Helsinki University Hospital Area
CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
Date: 2021-02-02
Language: eng
Number of pages: 6
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2020.604529
URI: http://hdl.handle.net/10138/328322
Abstract: Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8-22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease.
Subject: enterovirus
celiac disease
tissue transglutaminase autoantibodies
Finnish Diabetes Prediction and Prevention study
enzyme immunoassay (EIA)
conditional logistic regression
11832 Microbiology and virology
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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