Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study

Visa fullständig post



Permalänk

http://hdl.handle.net/10138/328322

Citation

Oikarinen , M , Puustinen , L , Lehtonen , J , Hakola , L , Simell , S , Toppari , J , Ilonen , J , Veijola , R , Virtanen , S M , Knip , M & Hyöty , H 2021 , ' Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study ' , Frontiers in Immunology , vol. 11 , 604529 . https://doi.org/10.3389/fimmu.2020.604529

Titel: Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
Författare: Oikarinen, Maarit; Puustinen, Leena; Lehtonen, Jussi; Hakola, Leena; Simell, Satu; Toppari, Jorma; Ilonen, Jorma; Veijola, Riitta; Virtanen, Suvi M.; Knip, Mikael; Hyöty, Heikki
Upphovmannens organisation: HUS Children and Adolescents
Children's Hospital
University of Helsinki
Helsinki University Hospital Area
CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
Datum: 2021-02-02
Språk: eng
Sidantal: 6
Tillhör serie: Frontiers in Immunology
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2020.604529
Permanenta länken (URI): http://hdl.handle.net/10138/328322
Abstrakt: Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8-22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease.
Subject: enterovirus
celiac disease
tissue transglutaminase autoantibodies
Finnish Diabetes Prediction and Prevention study
enzyme immunoassay (EIA)
conditional logistic regression
11832 Microbiology and virology
3121 General medicine, internal medicine and other clinical medicine
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


Filer under denna titel

Totalt antal nerladdningar: Laddar...

Filer Storlek Format Granska
fimmu_11_604529.pdf 525.2Kb PDF Granska/Öppna

Detta dokument registreras i samling:

Visa fullständig post