Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study

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dc.contributor.author Oikarinen, Maarit
dc.contributor.author Puustinen, Leena
dc.contributor.author Lehtonen, Jussi
dc.contributor.author Hakola, Leena
dc.contributor.author Simell, Satu
dc.contributor.author Toppari, Jorma
dc.contributor.author Ilonen, Jorma
dc.contributor.author Veijola, Riitta
dc.contributor.author Virtanen, Suvi M.
dc.contributor.author Knip, Mikael
dc.contributor.author Hyöty, Heikki
dc.date.accessioned 2021-03-24T10:47:01Z
dc.date.available 2021-03-24T10:47:01Z
dc.date.issued 2021-02-02
dc.identifier.citation Oikarinen , M , Puustinen , L , Lehtonen , J , Hakola , L , Simell , S , Toppari , J , Ilonen , J , Veijola , R , Virtanen , S M , Knip , M & Hyöty , H 2021 , ' Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study ' , Frontiers in Immunology , vol. 11 , 604529 . https://doi.org/10.3389/fimmu.2020.604529
dc.identifier.other PURE: 161462697
dc.identifier.other PURE UUID: e5e34c2d-6365-441a-a309-5ce815cfa856
dc.identifier.other WOS: 000618217200001
dc.identifier.uri http://hdl.handle.net/10138/328322
dc.description.abstract Enterovirus and adenovirus infections have been linked to the development of celiac disease. We evaluated this association in children who developed biopsy-proven celiac disease (N = 41) during prospective observation starting from birth, and in control children (N = 53) matched for the calendar time of birth, sex, and HLA-DQ genotype. Enterovirus and adenovirus infections were diagnosed by seroconversions in virus antibodies in longitudinally collected sera using EIA. Enterovirus infections were more frequent in case children before the appearance of celiac disease-associated tissue transglutaminase autoantibodies compared to the corresponding period in control children (OR 6.3, 95% CI 1.8-22.3; p = 0.005). No difference was observed in the frequency of adenovirus infections. The findings suggest that enterovirus infections may contribute to the process leading to celiac disease. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Frontiers in Immunology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject enterovirus
dc.subject celiac disease
dc.subject tissue transglutaminase autoantibodies
dc.subject Finnish Diabetes Prediction and Prevention study
dc.subject enzyme immunoassay (EIA)
dc.subject conditional logistic regression
dc.subject 11832 Microbiology and virology
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study en
dc.type Article
dc.contributor.organization HUS Children and Adolescents
dc.contributor.organization Children's Hospital
dc.contributor.organization University of Helsinki
dc.contributor.organization Helsinki University Hospital Area
dc.contributor.organization CAMM - Research Program for Clinical and Molecular Metabolism
dc.contributor.organization Faculty of Medicine
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3389/fimmu.2020.604529
dc.relation.issn 1664-3224
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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