Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life

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DIABIMMUNE Study Grp , Ruohtula , T , Kondrashova , A , Lehtonen , J , Oikarinen , S , Hämäläinen , A-M , Niemelä , O , Peet , A , Tillmann , V , Nieminen , J K , Ilonen , J , Knip , M , Vaarala , O & Hyöty , H 2021 , ' Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life ' , Frontiers in Immunology , vol. 11 , 567046 . https://doi.org/10.3389/fimmu.2020.567046

Title: Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life
Author: DIABIMMUNE Study Grp; Ruohtula, Terhi; Kondrashova, Anita; Lehtonen, Jussi; Oikarinen, Sami; Hämäläinen, Anu-Maaria; Niemelä, Onni; Peet, Aleksandr; Tillmann, Vallo; Nieminen, Janne K.; Ilonen, Jorma; Knip, Mikael; Vaarala, Outi; Hyöty, Heikki
Contributor organization: Clinicum
University of Helsinki
HUS Children and Adolescents
Children's Hospital
Helsinki University Hospital Area
Date: 2021-02-11
Language: eng
Number of pages: 10
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
DOI: https://doi.org/10.3389/fimmu.2020.567046
URI: http://hdl.handle.net/10138/328442
Abstract: Early childhood infections have been implicated in the development of immune-mediated diseases, such as allergies, asthma, and type 1 diabetes. We set out to investigate the immunomodulatory effects of early viral infections experienced before the age of one year on the peripheral regulatory T cell population (Treg) and circulating cytokines in a birth-cohort study of Estonian and Finnish infants. We show here a temporal association of virus infection with the expression of FOXP3 in regulatory T cells. Infants with rhinovirus infection during the preceding 30 days had a higher FOXP3 expression in Treg cells and decreased levels of several cytokines related to Th1 and Th2 responses in comparison to the children without infections. In contrast, FOXP3 expression was significantly decreased in highly activated (CD4+CD127-/loCD25+FOXP3high) regulatory T cells (TregFOXP3high) in the infants who had enterovirus infection during the preceding 30 or 60 days. After enterovirus infections, the cytokine profile showed an upregulation of Th1- and Th17-related cytokines and a decreased activation of CCL22, which is a chemokine derived from dendritic cells and associated with Th2 deviation. Our results reveal that immunoregulatory mechanisms are up-regulated after rhinovirus infections, while enterovirus infections are associated with activation of proinflammatory pathways and decreased immune regulation.
Subject: enterovirus
rhinovirus
regulatory T cell
cytokine
type 1 diabetes
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
11832 Microbiology and virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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