Long-term patient-important outcomes after septic shock : A protocol for 1-year follow-up of the CLASSIC trial

Show full item record



Permalink

http://hdl.handle.net/10138/328473

Citation

Kjaer , M-B N , Meyhoff , T S , Madsen , M B , Hjortrup , P B , Moller , M H , Egerod , I , Wetterslev , J , Lange , T , Cronhjort , M , Laake , J H , Jakob , S M , Nalos , M , Pettilä , V , van der Horst , I C C , Ostermann , M , Mouncey , P , Cecconi , M , Ferrer , R , Malbrain , M L N G , Ahlstedt , C , Hoffmann , S , Bestle , M H , Gyldensted , L , Nebrich , L , Russell , L , Vang , M , Solling , C , Brochner , A C , Rasmussen , B S & Perner , A 2020 , ' Long-term patient-important outcomes after septic shock : A protocol for 1-year follow-up of the CLASSIC trial ' , Acta Anaesthesiologica Scandinavica , vol. 64 , no. 3 , pp. 410-416 . https://doi.org/10.1111/aas.13519

Title: Long-term patient-important outcomes after septic shock : A protocol for 1-year follow-up of the CLASSIC trial
Author: Kjaer, Maj-Brit N.; Meyhoff, Tine S.; Madsen, Martin B.; Hjortrup, Peter B.; Moller, Morten Hylander; Egerod, Ingrid; Wetterslev, Jorn; Lange, Theis; Cronhjort, Maria; Laake, Jon H.; Jakob, Stephan M.; Nalos, Marek; Pettilä, Ville; van der Horst, Iwan C. C.; Ostermann, Marlies; Mouncey, Paul; Cecconi, Maurizio; Ferrer, Ricard; Malbrain, Manu L. N. G.; Ahlstedt, Christian; Hoffmann, Soren; Bestle, Morten H.; Gyldensted, Louise; Nebrich, Lars; Russell, Lene; Vang, Marianne; Solling, Christoffer; Brochner, Anne C.; Rasmussen, Bodil S.; Perner, Anders
Other contributor: University of Helsinki, HUS Perioperative, Intensive Care and Pain Medicine



Date: 2020-03
Language: eng
Number of pages: 7
Belongs to series: Acta Anaesthesiologica Scandinavica
ISSN: 0001-5172
DOI: https://doi.org/10.1111/aas.13519
URI: http://hdl.handle.net/10138/328473
Abstract: BackgroundIn patients with septic shock, mortality is high, and survivors experience long-term physical, mental and social impairments. The ongoing Conservative vs Liberal Approach to fluid therapy of Septic Shock in Intensive Care (CLASSIC) trial assesses the benefits and harms of a restrictive vs standard-care intravenous (IV) fluid therapy. The hypothesis is that IV fluid restriction improves patient-important long-term outcomes. AimTo assess the predefined patient-important long-term outcomes in patients randomised into the CLASSIC trial. MethodsIn this pre-planned follow-up study of the CLASSIC trial, we will assess all-cause mortality, health-related quality of life (HRQoL) and cognitive function 1 year after randomisation in the two intervention groups. The 1-year mortality will be collected from electronic patient records or central national registries in most participating countries. We will contact survivors and assess EuroQol 5-Dimension, -5-Level (EQ-5D-5L) and EuroQol-Visual Analogue Scale and Montreal Cognitive Assessment 5-minute protocol score. We will analyse mortality by logistic regression and use general linear models to assess HRQoL and cognitive function. DiscussionWith this pre-planned follow-up study of the CLASSIC trial, we will provide patient-important data on long-term survival, HRQoL and cognitive function of restrictive vs standard-care IV fluid therapy in patients with septic shock.
Subject: cognitive function
follow-up
HRQoL
IV fluid therapy
patient important outcomes
randomised clincial trial
QUALITY-OF-LIFE
RESPIRATORY-FAILURE SURVIVORS
MONTREAL COGNITIVE ASSESSMENT
INTENSIVE-CARE
CLINICAL-RESEARCH
SEPSIS
IMPAIRMENT
STRATEGIES
MANAGEMENT
HEALTH
3126 Surgery, anesthesiology, intensive care, radiology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Long_term_patie ... p_of_the_CLASSIC_trial.pdf 8.589Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record