Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders : A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches

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Psychiat Genomics Consortium , Yao , S , Kuja-Halkola , R , Martin , J , Kaprio , J , Keski-Rahkonen , A , Raevuori , A , Ripatti , S & Widen , E 2019 , ' Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders : A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches ' , Biological Psychiatry , vol. 86 , no. 8 , pp. 577-586 . https://doi.org/10.1016/j.biopsych.2019.04.036

Title: Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders : A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches
Author: Psychiat Genomics Consortium; Yao, Shuyang; Kuja-Halkola, Ralf; Martin, Joanna; Kaprio, Jaakko; Keski-Rahkonen, Anna; Raevuori, Anu; Ripatti, Samuli; Widen, Elisabeth
Contributor: University of Helsinki, Jaakko Kaprio / Principal Investigator
University of Helsinki, University Management
University of Helsinki, HUS Psychiatry
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2019-10-15
Language: eng
Number of pages: 10
Belongs to series: Biological Psychiatry
ISSN: 0006-3223
URI: http://hdl.handle.net/10138/328512
Abstract: BACKGROUND: Although attention-deficit/hyperactivity disorder (ADHD) and eating disorders (EDs) frequently cooccur, little is known about the shared etiology. In this study, we comprehensively investigated the genetic association between ADHD and various EDs, including anorexia nervosa (AN) and other EDs such as bulimia nervosa. METHODS: We applied different genetically informative designs to register-based information of a Swedish nationwide population (N = 3,550,118). We first examined the familial coaggregation of clinically diagnosed ADHD and EDs across multiple types of relatives. We then applied quantitative genetic modeling in full-sisters and maternal half-sisters to estimate the genetic correlations between ADHD and EDs. We further tested the associations between ADHD polygenic risk scores and ED symptoms, and between AN polygenic risk scores and ADHD symptoms, in a genotyped population-based sample (N = 13,472). RESULTS: Increased risk of all types of EDs was found in individuals with ADHD (any ED: odds ratio [OR] = 3.97, 95% confidence interval [CI] = 3.81, 4.14; AN: OR = 2.68, 95% CI = 2.15, 2.86; other EDs: OR = 4.66, 95% CI = 4.47, 4.87; bulimia nervosa: OR = 5.01, 95% CI = 4.63, 5.41) and their relatives compared with individuals without ADHD and their relatives. The magnitude of the associations decreased as the degree of relatedness decreased, suggesting shared familial liability between ADHD and EDs. Quantitative genetic models revealed stronger genetic correlation of ADHD with other EDs (.37, 95% CI = .31, .42) than with AN (.14, 95% CI = .05, .22). ADHD polygenic risk scores correlated positively with ED symptom measures overall and with the subscales Drive for Thinness and Body Dissatisfaction despite small effect sizes. CONCLUSIONS: We observed stronger genetic association with ADHD for non-AN EDs than for AN, highlighting specific genetic correlation beyond a general genetic factor across psychiatric disorders.
Subject: ADHD
Anorexia nervosa
Bulimia nervosa
Eating disorders
Genetic epidemiology
Polygenic risk score
ANOREXIA-NERVOSA
ADULTS
LISDEXAMFETAMINE
CHILDHOOD
OVERWEIGHT/OBESITY
COMORBIDITY
MORTALITY
LIABILITY
SYMPTOMS
3112 Neurosciences
3124 Neurology and psychiatry
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