A practical laboratory index to predict institutionalization and mortality - an 18-year population-based follow-up study

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dc.contributor.author Heikkilä, Elisa
dc.contributor.author Salminen, Marika
dc.contributor.author Viljanen, Anna
dc.contributor.author Katajamäki, Taina
dc.contributor.author Koivula, Marja-Kaisa
dc.contributor.author Pulkki, Kari
dc.contributor.author Isoaho, Raimo
dc.contributor.author Kivelä, Sirkka-Liisa
dc.contributor.author Viitanen, Matti
dc.contributor.author Löppönen, Minna
dc.contributor.author Vahlberg, Tero
dc.contributor.author Viikari, Laura
dc.contributor.author Irjala, Kerttu
dc.date.accessioned 2021-04-01T11:37:01Z
dc.date.available 2021-04-01T11:37:01Z
dc.date.issued 2021-02-25
dc.identifier.citation Heikkilä , E , Salminen , M , Viljanen , A , Katajamäki , T , Koivula , M-K , Pulkki , K , Isoaho , R , Kivelä , S-L , Viitanen , M , Löppönen , M , Vahlberg , T , Viikari , L & Irjala , K 2021 , ' A practical laboratory index to predict institutionalization and mortality - an 18-year population-based follow-up study ' , BMC Geriatrics , vol. 21 , no. 1 , 139 . https://doi.org/10.1186/s12877-021-02077-1
dc.identifier.other PURE: 161722240
dc.identifier.other PURE UUID: e589ea56-e66c-42db-8a20-29c2e574094c
dc.identifier.other WOS: 000624501200001
dc.identifier.uri http://hdl.handle.net/10138/328663
dc.description.abstract BackgroundPreviously, several indexes based on a large number of clinical and laboratory tests to predict mortality and frailty have been produced. However, there is still a need for an easily applicable screening tool for every-day clinical practice.MethodsA prospective study with 10- and 18-year follow-ups. Fourteen common laboratory tests were combined to an index. Cox regression model was used to analyse the association of the laboratory index with institutionalization and mortality.ResultsThe mean age of the participants (n =1153) was 73.6 (SD 6.8, range 64.0-100.0) years. Altogether, 151 (14.8%) and 305 (29.9%) subjects were institutionalized and 422 (36.6%) and 806 (69.9%) subjects deceased during the 10- and 18-year follow-ups, respectively. Higher LI (laboratory index) scores predicted increased mortality. Mortality rates increased as LI scores increased both in unadjusted and in age- and gender-adjusted models during both follow-ups. The LI did not significantly predict institutionalization either during the 10- or 18-year follow-ups.ConclusionsA practical index based on routine laboratory tests can be used to predict mortality among older people. An LI could be automatically counted from routine laboratory results and thus an easily applicable screening instrument in clinical settings. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof BMC Geriatrics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Laboratory index
dc.subject Institutionalization
dc.subject Mortality
dc.subject Aged
dc.subject 3141 Health care science
dc.title A practical laboratory index to predict institutionalization and mortality - an 18-year population-based follow-up study en
dc.type Article
dc.contributor.organization Department of Clinical Chemistry and Hematology
dc.contributor.organization Medicum
dc.contributor.organization University of Helsinki
dc.contributor.organization HUSLAB
dc.contributor.organization Divisions of Faculty of Pharmacy
dc.contributor.organization Division of Social Pharmacy
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/s12877-021-02077-1
dc.relation.issn 1471-2318
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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