beta 2 Integrin Signaling Cascade in Neutrophils : More Than a Single Function

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http://hdl.handle.net/10138/328828

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Bouti , P , Webbers , S D S , Fagerholm , S C , Alon , R , Moser , M , Matlung , H L & Kuijpers , T W 2021 , ' beta 2 Integrin Signaling Cascade in Neutrophils : More Than a Single Function ' , Frontiers in Immunology , vol. 11 , 619925 . https://doi.org/10.3389/fimmu.2020.619925

Title: beta 2 Integrin Signaling Cascade in Neutrophils : More Than a Single Function
Author: Bouti, Panagiota; Webbers, Steven D. S.; Fagerholm, Susanna C.; Alon, Ronen; Moser, Markus; Matlung, Hanke L.; Kuijpers, Taco W.
Contributor: University of Helsinki, Molecular and Integrative Biosciences Research Programme
Date: 2021-02-18
Number of pages: 20
Belongs to series: Frontiers in Immunology
ISSN: 1664-3224
URI: http://hdl.handle.net/10138/328828
Abstract: Neutrophils are the most prevalent leukocytes in the human body. They have a pivotal role in the innate immune response against invading bacterial and fungal pathogens, while recent emerging evidence also demonstrates their role in cancer progression and anti-tumor responses. The efficient execution of many neutrophil effector responses requires the presence of beta 2 integrins, in particular CD11a/CD18 or CD11b/CD18 heterodimers. Although extensively studied at the molecular level, the exact signaling cascades downstream of beta 2 integrins still remain to be fully elucidated. In this review, we focus mainly on inside-out and outside-in signaling of these two beta 2 integrin members expressed on neutrophils and describe differences between various neutrophil stimuli with respect to integrin activation, integrin ligand binding, and the pertinent differences between mouse and human studies. Last, we discuss how integrin signaling studies could be used to explore the therapeutic potential of targeting beta 2 integrins and the intracellular signaling cascade in neutrophils in several, among other, inflammatory conditions in which neutrophil activity should be dampened to mitigate disease.
Subject: CD11b
CD18 integrin
&#946
2 integrin signaling
neutrophils
neutrophil function
therapeutic targets
3121 Internal medicine
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