A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies

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http://hdl.handle.net/10138/328924

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Jääskeläinen , T , Kärkkäinen , O , Jokkala , J , Klåvus , A , Heinonen , S , Auriola , S , Lehtonen , M , FINNPEC Core Invest Grp , Hanhineva , K & Laivuori , H 2021 , ' A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies ' , Metabolomics , vol. 17 , 20 . https://doi.org/10.1007/s11306-020-01752-5

Title: A non-targeted LC-MS metabolic profiling of pregnancy: longitudinal evidence from healthy and pre-eclamptic pregnancies
Author: Jääskeläinen, Tiina; Kärkkäinen, Olli; Jokkala, Jenna; Klåvus, Anton; Heinonen, Seppo; Auriola, Seppo; Lehtonen, Marko; FINNPEC Core Invest Grp; Hanhineva, Kati; Laivuori, Hannele
Contributor organization: Department of Food and Nutrition
Pregnancy and Genes
Medicum
HUS Gynecology and Obstetrics
Department of Obstetrics and Gynecology
Genomics of Neurological and Neuropsychiatric Disorders
Institute for Molecular Medicine Finland
Date: 2021-01-29
Language: eng
Number of pages: 12
Belongs to series: Metabolomics
ISSN: 1573-3882
DOI: https://doi.org/10.1007/s11306-020-01752-5
URI: http://hdl.handle.net/10138/328924
Abstract: IntroductionMaternal metabolism changes substantially during pregnancy. However, few studies have used metabolomics technologies to characterize changes across gestation.Objectives and methodsWe applied liquid chromatography-mass spectrometry (LC-MS) based non-targeted metabolomics to determine whether the metabolic profile of serum differs throughout the pregnancy between pre-eclamptic and healthy women in the FINNPEC (Finnish Genetics of Preeclampsia Consortium) Study. Serum samples were available from early and late pregnancy.ResultsProgression of pregnancy had large-scale effects to the serum metabolite profile. Altogether 50 identified metabolites increased and 49 metabolites decreased when samples of early pregnancy were compared to samples of late pregnancy. The metabolic signatures of pregnancy were largely shared in pre-eclamptic and healthy women, only urea, monoacylglyceride 18:1 and glycerophosphocholine were identified to be increased in the pre-eclamptic women when compared to healthy controls.ConclusionsOur study highlights the need of large-scale longitudinal metabolomic studies in non-complicated pregnancies before more detailed understanding of metabolism in adverse outcomes could be provided. Our findings are one of the first steps for a broader metabolic understanding of the physiological changes caused by pregnancy per se.
Subject: AMINO-ACID-CONCENTRATIONS
BIRTH-WEIGHT
CHOLINE
CONSUMPTION
CORD PLASMA
FETAL
HIPPURIC-ACID
LC-MS
MATERNAL METABOLISM
Metabolomics
Preeclampsia
Pregnancy
SAMPLES
URINE
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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