Effect of colloidal silicon dioxide and moisture on powder flow properties : Predicting in-process performance using image-based analysis

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http://hdl.handle.net/10138/328949

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Blanco , D , Antikainen , O , Räikkönen , H , Yliruusi , J & Juppo , A M 2021 , ' Effect of colloidal silicon dioxide and moisture on powder flow properties : Predicting in-process performance using image-based analysis ' , International Journal of Pharmaceutics , vol. 597 , 120344 . https://doi.org/10.1016/j.ijpharm.2021.120344

Title: Effect of colloidal silicon dioxide and moisture on powder flow properties : Predicting in-process performance using image-based analysis
Author: Blanco, David; Antikainen, Osmo; Räikkönen, Heikki; Yliruusi, Jouko; Juppo, Anne Mari
Other contributor: University of Helsinki, Divisions of Faculty of Pharmacy
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Divisions of Faculty of Pharmacy
University of Helsinki, Division of Pharmaceutical Chemistry and Technology






Date: 2021-03-15
Language: eng
Number of pages: 7
Belongs to series: International Journal of Pharmaceutics
ISSN: 0378-5173
DOI: https://doi.org/10.1016/j.ijpharm.2021.120344
URI: http://hdl.handle.net/10138/328949
Abstract: The effect of colloidal silicon dioxide (CSD) on powder flow properties of poor-flowing excipient lactose 200 M was investigated. Binary mixtures of different ratios of CSD as glidant were examined using a modern imagebased flow measuring technique. Special attention was placed to subtle variations in powder flow from small changes in glidant concentration (0.025% w/w). Understanding the modes of interaction of particles and their effects on flowability using the method predicted the die filling performance during tablet manufacture. In addition, the importance of moisture content on powder flow properties was empirically underlined. A more efficient range of CSD was detected from 0.10 to 0.50% w/w in most of the tested conditions, which revealed a significant improvement in powder flow performance compared to higher amounts typically handled in the pharmaceutical industry.
Subject: Powder flow
Colloidal silicon dioxide
Moisture
Lactose
Cohesive powders
Image analysis
Tablet manufacture
317 Pharmacy
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