Ecotoxic effects of loratadine and its metabolic and light-induced derivatives

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http://hdl.handle.net/10138/329052

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Iesce , M R , Lavorgna , M , Russo , C , Piscitelli , C , Passananti , M , Temussi , F , DellaGreca , M , Cermola , F & Isidori , M 2019 , ' Ecotoxic effects of loratadine and its metabolic and light-induced derivatives ' , Ecotoxicology and Environmental Safety , vol. 170 , pp. 664-672 . https://doi.org/10.1016/j.ecoenv.2018.11.116

Title: Ecotoxic effects of loratadine and its metabolic and light-induced derivatives
Author: Iesce, Maria Rosaria; Lavorgna, Margherita; Russo, Chiara; Piscitelli, Concetta; Passananti, Monica; Temussi, Fabio; DellaGreca, Marina; Cermola, Flavio; Isidori, Marina
Other contributor: University of Helsinki, Institute for Atmospheric and Earth System Research (INAR)

Date: 2019-04-15
Language: eng
Number of pages: 9
Belongs to series: Ecotoxicology and Environmental Safety
ISSN: 0147-6513
DOI: https://doi.org/10.1016/j.ecoenv.2018.11.116
URI: http://hdl.handle.net/10138/329052
Abstract: Loratadine and desloratadine are second-generation antihistaminic drugs. Because of human administration, they are continuously released via excreta into wastewater treatment plants and occur in surface waters as residues and transformation products (TPs). Loratadine and desloratadine residues have been found at very low concentrations (ng/L) in the aquatic environment but their toxic effects are still not well known. Both drugs are light-sensitive even under environmentally simulated conditions and some of the photoproducts have been isolated and characterized. The aim of the present study was to investigate the acute and chronic ecotoxicity of loratadine, desloratadine and their light-induced transformation products in organisms of the aquatic trophic chain. Bioassays were performed in the alga Pseudokirchneriella subcapitata, the rotifer Brachionus calyciflorus and in two crustaceans, Thamnocephalus platyurus and Ceriodaphnia dubia. Loratadine exerted its acute and chronic toxicity especially on Ceriodaphnia dubia (LC50: 600 mu g/L, EC50: 28.14 mu g/L) while desloratadine showed similar acute toxicity among the organisms tested and it was the most chronically effective compound in Ceriodaphnia dubia and Pseudokirchneriella subcapitata. Generally, transformation products were less active in both acute and chronic assays.
Subject: Antihistaminic drug
Loratadine
Desloratadine
Acute toxicity
Chronic toxicity
Photoproducts
PHARMACEUTICALS
WATER
DIPHENHYDRAMINE
TOXICITY
ANTIHISTAMINES
IDENTIFICATION
TRANSFORMATION
PHARMACOLOGY
TOXICOLOGY
SERTRALINE
1172 Environmental sciences
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