Childhood risk factors and carotid atherosclerotic plaque in adulthood : The Cardiovascular Risk in Young Finns Study

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dc.contributor.author Koskinen, Juhani S.
dc.contributor.author Kytö, Ville
dc.contributor.author Juonala, Markus
dc.contributor.author Viikari, Jorma S. A.
dc.contributor.author Nevalainen, Jaakko
dc.contributor.author Kähönen, Mika
dc.contributor.author Lehtimäki, Terho
dc.contributor.author Hutri-Kähönen, Nina
dc.contributor.author Laitinen, Tomi
dc.contributor.author Tossavainen, Päivi
dc.contributor.author Jokinen, Eero
dc.contributor.author Magnussen, Costan G.
dc.contributor.author Raitakari, Olli T.
dc.date.accessioned 2021-04-15T12:12:01Z
dc.date.available 2021-04-15T12:12:01Z
dc.date.issued 2020-01
dc.identifier.citation Koskinen , J S , Kytö , V , Juonala , M , Viikari , J S A , Nevalainen , J , Kähönen , M , Lehtimäki , T , Hutri-Kähönen , N , Laitinen , T , Tossavainen , P , Jokinen , E , Magnussen , C G & Raitakari , O T 2020 , ' Childhood risk factors and carotid atherosclerotic plaque in adulthood : The Cardiovascular Risk in Young Finns Study ' , Atherosclerosis , vol. 293 , pp. 18-25 . https://doi.org/10.1016/j.atherosclerosis.2019.11.029
dc.identifier.other PURE: 159884716
dc.identifier.other PURE UUID: 367bf3d8-8adb-43c4-8b6c-cb499a168786
dc.identifier.other WOS: 000506889300003
dc.identifier.uri http://hdl.handle.net/10138/329087
dc.description.abstract Background and aims: Carotid plaque is a specific sign of atherosclerosis and adults with carotid plaque are at increased risk for cardiovascular outcomes. Atherosclerosis has roots in childhood and pediatric guidelines provide cut-off values for cardiovascular risk factors. However, it is unknown whether these cut-offs predict adulthood advanced atherosclerosis. Methods: The Cardiovascular Risk in Young Finns Study is a follow-up of children that begun in 1980 when 2653 participants with data for the present analyses were aged 3-18 years. In 2001 and 2007 follow-ups, in addition to adulthood cardiovascular risk factors, carotid ultrasound data was collected. Long-term burden, as the area under the curve, was evaluated for childhood (6-18 years) risk factors. To study the associations of guideline-based cut-offs with carotid plaque, both childhood and adult risk factors were classified according to clinical practice guidelines. Results: Carotid plaque, defined as a focal structure of the arterial wall protruding into lumen > 50% compared to adjacent intima-media thickness, was present in 88 (3.3%) participants. Relative risk for carotid plaque, when adjusted for age and sex, was 3.03 (95% CI, 1.76-5.21) for childhood dyslipidemia, 1.51 (95% CI, 0.99-2.32) for childhood elevated systolic blood pressure, and 1.93 (95% CI, 1.26-2.94) for childhood smoking. Childhood dyslipidemia and smoking remained independent predictors of carotid plaque in models additionally adjusted for adult risk factors and family history of coronary heart disease. Carotid plaque was present in less than 1% of adults with no childhood risk factors. Conclusions: Findings reinforce childhood prevention efforts and demonstrate the utility of guideline-based cutoffs in identifying children at increased risk for adulthood atherosclerosis. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Atherosclerosis
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Atherosclerosis
dc.subject Carotid atherosclerotic plaque
dc.subject Childhood cardiovascular risk factors
dc.subject Cardiovascular risk factor cut-offs
dc.subject Area under the curve - Childhood risk factor long-term burden
dc.subject INTIMA-MEDIA THICKNESS
dc.subject DENSITY-LIPOPROTEIN CHOLESTEROL
dc.subject CORONARY-ARTERY CALCIFICATION
dc.subject COHORT PROFILE
dc.subject CHILDREN
dc.subject DETERMINANTS
dc.subject ASSOCIATION
dc.subject PROGRESSION
dc.subject PREVALENCE
dc.subject ADIPOSITY
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Childhood risk factors and carotid atherosclerotic plaque in adulthood : The Cardiovascular Risk in Young Finns Study en
dc.type Article
dc.contributor.organization Children's Hospital
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization HUS Children and Adolescents
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.atherosclerosis.2019.11.029
dc.relation.issn 0021-9150
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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