Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor

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Li , H , Hohenstein , P & Kuure , S 2021 , ' Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor ' , Genes , vol. 12 , no. 2 , 318 . https://doi.org/10.3390/genes12020318

Title: Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor
Author: Li, Hao; Hohenstein, Peter; Kuure, Satu
Contributor organization: Helsinki Institute of Life Science HiLIFE
Kidney development
STEMM - Stem Cells and Metabolism Research Program
Faculty of Medicine
University of Helsinki
Helsinki Institute of Life Science HiLIFE, Infra
Biosciences
Research Programs Unit
Date: 2021-02
Language: eng
Number of pages: 21
Belongs to series: Genes
ISSN: 2073-4425
DOI: https://doi.org/10.3390/genes12020318
URI: http://hdl.handle.net/10138/329179
Abstract: The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that could replenish functional homeostasis similarly to, e.g., skin or the hematopoietic system. Unlike a mature kidney, the embryonic kidney hosts at least three types of lineage-specific stem cells that give rise to (a) a ureter and collecting duct system, (b) nephrons, and (c) mesangial cells together with connective tissue of the stroma. Extensive interest has been raised towards these embryonic progenitor cells, which are normally lost before birth in humans but remain part of the undifferentiated nephrogenic rests in the pediatric renal cancer Wilms tumor. Here, we discuss the current understanding of kidney-specific embryonic progenitor regulation in the innate environment of the developing kidney and the types of disruptions in their balanced regulation that lead to the formation of Wilms tumor.
Subject: kidney
organogenesis
pediatric cancer
stem cells
differentiation
self-renewal
NEPHRON PROGENITOR CELLS
DEVELOPING MOUSE KIDNEY
URETERAL BUD
BRANCHING MORPHOGENESIS
GENE-EXPRESSION
BETA-CATENIN
TRANSCRIPTION FACTOR
STROMAL PROGENITORS
NEUROTROPHIC FACTOR
SELF-RENEWAL
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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