Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era

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Pöntinen , A K , Top , J , Arredondo-Alonso , S , Tonkin-Hill , G , Freitas , A R , Novais , C , Gladstone , R A , Pesonen , M , Meneses , R , Pesonen , H , Lees , J A , Jamrozy , D , Bentley , S D , Lanza , V F , Torres , C , Peixe , L , Coque , T M , Parkhill , J , Schurch , A C , Willems , R J L & Corander , J 2021 , ' Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era ' , Nature Communications , vol. 12 , no. 1 , 1523 . https://doi.org/10.1038/s41467-021-21749-5

Title: Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era
Author: Pöntinen, Anna K.; Top, Janetta; Arredondo-Alonso, Sergio; Tonkin-Hill, Gerry; Freitas, Ana R.; Novais, Carla; Gladstone, Rebecca A.; Pesonen, Maiju; Meneses, Rodrigo; Pesonen, Henri; Lees, John A.; Jamrozy, Dorota; Bentley, Stephen D.; Lanza, Val F.; Torres, Carmen; Peixe, Luisa; Coque, Teresa M.; Parkhill, Julian; Schurch, Anita C.; Willems, Rob J. L.; Corander, Jukka
Contributor: University of Helsinki, University of Oslo
University of Helsinki, Helsinki Institute for Information Technology
Date: 2021-03-09
Language: eng
Number of pages: 13
Belongs to series: Nature Communications
ISSN: 2041-1723
URI: http://hdl.handle.net/10138/329311
Abstract: Enterococcus faecalis is a commensal and nosocomial pathogen, which is also ubiquitous in animals and insects, representing a classical generalist microorganism. Here, we study E. faecalis isolates ranging from the pre-antibiotic era in 1936 up to 2018, covering a large set of host species including wild birds, mammals, healthy humans, and hospitalised patients. We sequence the bacterial genomes using short- and long-read techniques, and identify multiple extant hospital-associated lineages, with last common ancestors dating back as far as the 19th century. We find a population cohesively connected through homologous recombination, a metabolic flexibility despite a small genome size, and a stable large core genome. Our findings indicate that the apparent hospital adaptations found in hospital-associated E. faecalis lineages likely predate the "modern hospital" era, suggesting selection in another niche, and underlining the generalist nature of this nosocomial pathogen.Enterococcus faecalis is a commensal microorganism of animals, insects and humans, but also a nosocomial pathogen. Here, the authors analyse genomic sequences from E. faecalis isolates from animals and humans, and find that the last common ancestors of multiple hospital-associated lineages date to the pre-antibiotic era.
Subject: 1184 Genetics, developmental biology, physiology
112 Statistics and probability
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