Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era

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dc.contributor.author Pöntinen, Anna K.
dc.contributor.author Top, Janetta
dc.contributor.author Arredondo-Alonso, Sergio
dc.contributor.author Tonkin-Hill, Gerry
dc.contributor.author Freitas, Ana R.
dc.contributor.author Novais, Carla
dc.contributor.author Gladstone, Rebecca A.
dc.contributor.author Pesonen, Maiju
dc.contributor.author Meneses, Rodrigo
dc.contributor.author Pesonen, Henri
dc.contributor.author Lees, John A.
dc.contributor.author Jamrozy, Dorota
dc.contributor.author Bentley, Stephen D.
dc.contributor.author Lanza, Val F.
dc.contributor.author Torres, Carmen
dc.contributor.author Peixe, Luisa
dc.contributor.author Coque, Teresa M.
dc.contributor.author Parkhill, Julian
dc.contributor.author Schurch, Anita C.
dc.contributor.author Willems, Rob J. L.
dc.contributor.author Corander, Jukka
dc.date.accessioned 2021-04-22T14:21:01Z
dc.date.available 2021-04-22T14:21:01Z
dc.date.issued 2021-03-09
dc.identifier.citation Pöntinen , A K , Top , J , Arredondo-Alonso , S , Tonkin-Hill , G , Freitas , A R , Novais , C , Gladstone , R A , Pesonen , M , Meneses , R , Pesonen , H , Lees , J A , Jamrozy , D , Bentley , S D , Lanza , V F , Torres , C , Peixe , L , Coque , T M , Parkhill , J , Schurch , A C , Willems , R J L & Corander , J 2021 , ' Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era ' , Nature Communications , vol. 12 , no. 1 , 1523 . https://doi.org/10.1038/s41467-021-21749-5
dc.identifier.other PURE: 162438484
dc.identifier.other PURE UUID: 8b28ce23-212e-410c-b43d-4e07785ccd3d
dc.identifier.other WOS: 000627829600009
dc.identifier.other ORCID: /0000-0002-5806-8572/work/92662277
dc.identifier.uri http://hdl.handle.net/10138/329311
dc.description.abstract Enterococcus faecalis is a commensal and nosocomial pathogen, which is also ubiquitous in animals and insects, representing a classical generalist microorganism. Here, we study E. faecalis isolates ranging from the pre-antibiotic era in 1936 up to 2018, covering a large set of host species including wild birds, mammals, healthy humans, and hospitalised patients. We sequence the bacterial genomes using short- and long-read techniques, and identify multiple extant hospital-associated lineages, with last common ancestors dating back as far as the 19th century. We find a population cohesively connected through homologous recombination, a metabolic flexibility despite a small genome size, and a stable large core genome. Our findings indicate that the apparent hospital adaptations found in hospital-associated E. faecalis lineages likely predate the "modern hospital" era, suggesting selection in another niche, and underlining the generalist nature of this nosocomial pathogen.Enterococcus faecalis is a commensal microorganism of animals, insects and humans, but also a nosocomial pathogen. Here, the authors analyse genomic sequences from E. faecalis isolates from animals and humans, and find that the last common ancestors of multiple hospital-associated lineages date to the pre-antibiotic era. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Nature Communications
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 1184 Genetics, developmental biology, physiology
dc.subject 112 Statistics and probability
dc.title Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era en
dc.type Article
dc.contributor.organization Helsinki Institute for Information Technology
dc.contributor.organization Jukka Corander / Principal Investigator
dc.contributor.organization Department of Mathematics and Statistics
dc.contributor.organization Biostatistics Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41467-021-21749-5
dc.relation.issn 2041-1723
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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