Panel 3: Genomics, precision medicine and targeted therapies

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http://hdl.handle.net/10138/329316

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Santos-Cortez , R L P , Bhutta , M F , Earl , J P , Hafrén , L , Jennings , M , Mell , J C , Pichichero , M E , Ryan , A F , Tateossian , H & Ehrlich , G D 2020 , ' Panel 3: Genomics, precision medicine and targeted therapies ' , International Journal of Pediatric Otorhinolaryngology , vol. 130 , 109835 . https://doi.org/10.1016/j.ijporl.2019.109835

Title: Panel 3: Genomics, precision medicine and targeted therapies
Author: Santos-Cortez, R.L.P.; Bhutta, M.F.; Earl, J.P.; Hafrén, Lena; Jennings, M.; Mell, J.C.; Pichichero, M.E.; Ryan, A.F.; Tateossian, Hilda; Ehrlich, G.D.
Contributor: University of Helsinki, HUS Head and Neck Center
Date: 2020-03
Language: eng
Number of pages: 14
Belongs to series: International Journal of Pediatric Otorhinolaryngology
ISSN: 0165-5876
URI: http://hdl.handle.net/10138/329316
Abstract: Objective: To review the most recent advances in human and bacterial genomics as applied to pathogenesis and clinical management of otitis media. Data sources: PubMed articles published since the last meeting in June 2015 up to June 2019. Review methods: A panel of experts in human and bacterial genomics of otitis media was formed. Each panel member reviewed the literature in their respective fields and wrote draft reviews. The reviews were shared with all panel members, and a merged draft was created. The panel met at the 20th International Symposium on Recent Advances in Otitis Media in June 2019, discussed the review and refined the content. A final draft was made, circulated, and approved by the panel members. Conclusion: Trans-disciplinary approaches applying pan-omic technologies to identify human susceptibility to otitis media and to understand microbial population dynamics, patho-adaptation and virulence mechanisms are crucial to the development of novel, personalized therapeutics and prevention strategies for otitis media. Implications for practice: In the future otitis media prevention strategies may be augmented by mucosal immunization, combination vaccines targeting multiple pathogens, and modulation of the middle ear microbiome. Both treatment and vaccination may be tailored to an individual's otitis media phenotype as defined by molecular profiles obtained by using rapidly developing techniques in microbial and host genomics. © 2020 Elsevier B.V.
Subject: Genome-wide association study
Metagenomics
Microbiome
Otitis media
Otitis-prone
Precision medicine
amoxicillin
ciprofloxacin
corticosteroid
Haemophilus influenzae vaccine
mannoside
Pneumococcus vaccine
Pneumococcus vaccine 15
Pneumococcus vaccine 20
RNA 16S
unclassified drug
Article
bacterial virulence
disease predisposition
genetic regulation
genomics
Haemophilus infection
health care management
human
immunization
microbial community
microbial genetics
microbiome
nonhuman
otitis media
pathogenesis
personalized medicine
phenotype
pneumococcal infection
priority journal
RNA sequencing
systematic review
animal
genetic predisposition
genetics
microbiology
microflora
middle ear
Animals
Ear, Middle
Genetic Predisposition to Disease
Genomics
Humans
Microbiota
Otitis Media
Precision Medicine
3125 Otorhinolaryngology, ophthalmology
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