An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity

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Es-safi , I , Mechchate , H , Amaghnouje , A , Jawhari , F Z , Al Kamaly , O M , Imtara , H , Grafov , A , Bari , A & Bousta , D 2021 , ' An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity ' , Life (Basel) , vol. 11 , no. 3 , 207 . https://doi.org/10.3390/life11030207

Title: An Insight into the Anxiolytic and Antidepressant-Like Proprieties of Carum carvi L. and Their Association with Its Antioxidant Activity
Author: Es-safi, Imane; Mechchate, Hamza; Amaghnouje, Amal; Jawhari, Fatima Zahra; Al Kamaly, Omkulthom Mohamed; Imtara, Hamada; Grafov, Andriy; Bari, Amina; Bousta, Dalila
Contributor organization: Department of Chemistry
Date: 2021-03
Language: eng
Number of pages: 14
Belongs to series: Life (Basel)
ISSN: 2075-1729
DOI: https://doi.org/10.3390/life11030207
URI: http://hdl.handle.net/10138/329329
Abstract: Depression and anxiety are widespread illnesses whose consequences on patients' social and professional lives are becoming ever more dangerous and severe. The study's objective is to explore the antidepressant-like and anxiolytic activity of the polyphenolic extract of Carum carvi L. as well as its antioxidant power as they were recently associated. The predictive antidepressant activity was evaluated using the forced swimming and tail suspension test in mice, a preclinical behavioral model widely used to determine the efficacy of antidepressant drugs. As for anxiolytic-like activity, two models were used, namely the light/dark chamber test to measure the animal's degree of anxiety and the open field test to evaluate both anxiolytic and locomotor activity. The tests results indicate a remarkable antidepressant and anxiolytic-like effect after oral administration of the polyphenolic fraction of C. carvi and interesting antioxidant property. In the extract it has been confirmed the presence of 6 molecules belonging to polyphenols, identified with HPLC analysis. This study confirms and encourages the traditional use of the extract and appeals to further studies to understand its action mechanism.
Subject: antidepressant-like
anxiolytic
antioxidant
Carum carvi L
polyphenols
tail suspension test
light-dark chamber test
forced swim test
open field test
DPPH test
FRAP test
116 Chemical sciences
317 Pharmacy
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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