CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria

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Jones , M R , Pinto , E , Torres , M A , Dörr , F , Mazur-Marzec , H , Szubert , K , Tartaglione , L , Dell'Aversano , C , Miles , C O , Beach , D G , McCarron , P , Sivonen , K , Fewer , D P , Jokela , J & Janssen , E M-L 2021 , ' CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria ' , Water Research , vol. 196 , 117017 . https://doi.org/10.1016/j.watres.2021.117017

Title: CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria
Author: Jones, Martin R.; Pinto, Ernani; Torres, Mariana A.; Dörr, Fabiane; Mazur-Marzec, Hanna; Szubert, Karolina; Tartaglione, Luciana; Dell'Aversano, Carmela; Miles, Christopher O.; Beach, Daniel G.; McCarron, Pearse; Sivonen, Kaarina; Fewer, David P.; Jokela, Jouni; Janssen, Elisabeth M.-L.
Other contributor: University of Helsinki, Department of Microbiology
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Faculty of Agriculture and Forestry





Date: 2021-05-15
Language: eng
Number of pages: 12
Belongs to series: Water Research
ISSN: 0043-1354
DOI: https://doi.org/10.1016/j.watres.2021.117017
URI: http://hdl.handle.net/10138/329369
Abstract: Harmful cyanobacterial blooms, which frequently contain toxic secondary metabolites, are reported in aquatic environments around the world. More than two thousand cyanobacterial secondary metabolites have been reported from diverse sources over the past fifty years. A comprehensive, publically-accessible database detailing these secondary metabolites would facilitate research into their occurrence, functions and toxicological risks. To address this need we created CyanoMetDB, a highly curated, flat-file, openly-accessible database of cyanobacterial secondary metabolites collated from 850 peer-reviewed articles published between 1967 and 2020. CyanoMetDB contains 2010 cyanobacterial metabolites and 99 structurally related compounds. This has nearly doubled the number of entries with complete literature metadata and structural composition information compared to previously available open access databases. The dataset includes microcytsins, cyanopeptolins, other depsipeptides, anabaenopeptins, microginins, aeruginosins, cyclamides, cryptophycins, saxitoxins, spumigins, microviridins, and anatoxins among other metabolite classes. A comprehensive database dedicated to cyanobacterial secondary metabolites facilitates: (1) the detection and dereplication of known cyanobacterial toxins and secondary metabolites; (2) the identification of novel natural products from cyanobacteria; (3) research on biosynthesis of cyanobacterial secondary metabolites, including substructure searches; and (4) the investigation of their abundance, persistence, and toxicity in natural environments.
Subject: Cyanobacteria
Secondary metabolite
Database
Toxin
Cyanopeptide
CyanoMetDB
ANATOXIN-A
RESERVOIR
NATURAL-PRODUCTS
DISCOVERY
PEPTIDES
MICROCYSTINS
GENE-CLUSTER
BIOSYNTHESIS
DIVERSITY
INHIBITORS
11832 Microbiology and virology
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