Overweight, obesity and hyperandrogenemia are associated with gestational diabetes mellitus : A follow-up cohort study

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West , S , Ollila , M-M , Franks , S , Piltonen , T , Jokelainen , J , Nevalainen , J , Puukka , K , Ruokonen , A , Järvelin , M-R , Auvinen , J , Tapanainen , J S & Morin-Papunen , L 2020 , ' Overweight, obesity and hyperandrogenemia are associated with gestational diabetes mellitus : A follow-up cohort study ' , Acta Obstetricia et Gynecologica Scandinavica , vol. 99 , no. 10 , pp. 1311-1319 . https://doi.org/10.1111/aogs.13883

Title: Overweight, obesity and hyperandrogenemia are associated with gestational diabetes mellitus : A follow-up cohort study
Author: West, Sammeli; Ollila, Meri-Maija; Franks, Stephen; Piltonen, Terhi; Jokelainen, Jari; Nevalainen, Jaana; Puukka, Katri; Ruokonen, Aimo; Järvelin, Marjo-Riitta; Auvinen, Juha; Tapanainen, Juha S.; Morin-Papunen, Laure
Contributor: University of Helsinki, HUS Gynecology and Obstetrics
Date: 2020-10
Language: eng
Number of pages: 9
Belongs to series: Acta Obstetricia et Gynecologica Scandinavica
ISSN: 0001-6349
URI: http://hdl.handle.net/10138/329372
Abstract: Introduction The aim of the study was to determine the association of body mass index (BMI), self-reported symptoms or diagnosis of polycystic ovary syndrome (PCOS), and hyperandrogenemia with the occurrence of gestational diabetes mellitus (GDM) through reproductive life. Material and methods A cohort of women born in 1966 were investigated at ages 14, 31 and 46. Women with self-reported PCOS symptoms (presence of both oligo-amenorrhea and hirsutism) at age 31 or with formally diagnosed polycystic ovaries (PCO)/PCOS by age 46 formed the group of self-reported PCOS (srPCOS, n = 222) and were compared with women without self-reported PCOS symptoms or diagnosis (n = 1357). We investigated also the association of hyperandrogenism (hirsutism or biochemical hyperandrogenism) at age 31 with the occurrence of GDM throughout reproductive life. Results Self-reported PCOS alone was not a risk factor for GDM, but combined with overweight at age 31 (odds ratio [OR] 2.43, 95% confidence interval [CI] 1.22-4.86) or 46 (OR 3.04, 95% CI 1.58-5.83) srPCOS was associated with GDM when compared with normal weight controls. The association disappeared when comparing overweight srPCOS women with overweight controls. However, hyperandrogenemia at age 31, but not hirsutism, was associated with GDM even after adjustment for BMI. Conclusions The increased risk of GDM in women with srPCOS was mostly attributed to overweight or obesity. Importantly, normal weight women with srPCOS did not seem to be at increased risk for developing GDM. However, hyperandrogenemia was associated with GDM even after adjustment for BMI. These findings strengthen the importance of weight management in reproductive-age women and suggest a noteworthy role of hyperandrogenemia in the pathophysiology of GDM.
Subject: Follow-up cohort study
Gestational diabetes mellitus
Hyperandrogenism
Overweight
Polycystic ovary syndrome
POLYCYSTIC-OVARY-SYNDROME
hyperandrogenism
RISK
gestational diabetes mellitus
PREVALENCE
follow-up cohort study
polycystic ovary syndrome
WOMEN
PROFILE
SELF-REPORTED SYMPTOMS
OLIGOMENORRHEA AND/OR HIRSUTISM
COMPLICATIONS
HEALTH
overweight
3123 Gynaecology and paediatrics
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