Associations of overweight and metabolic health with successful aging : 32-year follow-up of the Helsinki Businessmen Study

Show full item record



Permalink

http://hdl.handle.net/10138/329506

Citation

Jyväkorpi , S K , Urtamo , A , Strandberg , A Y , von Bonsdorff , M , Salomaa , V , Kivimäki , M , Luotola , K & Strandberg , T E 2020 , ' Associations of overweight and metabolic health with successful aging : 32-year follow-up of the Helsinki Businessmen Study ' , Clinical Nutrition , vol. 39 , no. 5 , pp. 1491-1496 . https://doi.org/10.1016/j.clnu.2019.06.011

Title: Associations of overweight and metabolic health with successful aging : 32-year follow-up of the Helsinki Businessmen Study
Author: Jyväkorpi, Satu K.; Urtamo, Annele; Strandberg, Arto Y.; von Bonsdorff, Mikaela; Salomaa, Veikko; Kivimäki, Mika; Luotola, Kari; Strandberg, Timo E.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, HUS Internal Medicine and Rehabilitation
Date: 2020-05
Language: eng
Number of pages: 6
Belongs to series: Clinical Nutrition
ISSN: 0261-5614
URI: http://hdl.handle.net/10138/329506
Abstract: Background & aims: Prognostic significance of metabolically healthy overweight and obesity (MHO) is under debate. However the relationship between MHO and health-related quality of life (HRQoL) is less studied. We compared successful aging (longevity plus HRQoL) in men with MHO, metabolically healthy normal weight (MHN) and metabolically unhealthy overweight and obesity (MUO). Methods: In the Helsinki Businessmen Study longitudinal cohort, consisting of men born 1919 to 1934. In 1985/86, overweight (BMI >= 25 kg/m(2)) and metabolic health were determined in 1309 men (median age 60 years). HRQoL was assessed using RAND-36/SF-36 in 2000 and 2007, and all-cause mortality retrieved from registers up to 2018. The proportion of men reaching 90 years was also calculated. Results: Of the men, 469 (35.8%), 538 (41.1%), 276 (21.1%), and 26 (2.0%) were MHN, MHO, MUO and MUN, respectively. During the 32-year follow-up, 72.3% men died. With MHN as reference, adjusted hazard ratio with all-cause mortality was 1.08 (95% confidence interval [CI] 0.93 to 1.27) for MHO, and 1.18 (95% CI 0.95 to 1.47) for MUO. During follow-up, 273 men reached 90 years. With MHN as reference, adjusted odds ratio for MHO was 0.82 (95% CI 0.59 to 1.14) and 0.62 (95% CI 0.41 to 0.95) for MUO. Men in MHN group scored generally highest in RAND-36 HRQoL subscales in 2000 and 2007, of those significantly better in Physical functioning, Role physical, Role emotional, Bodily Pain, and General health sub-scales compared to MHO group in 2000. Conclusions: As compared to MHN, MHO in late midlife does not increase mortality, but impairs odds for successful aging. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Subject: Quality of life
RAND-36
Nonagenarians
Successful aging
Metabolically healthy overweight and obesity
Metabolically unhealthy overweight and obesity
BODY-MASS INDEX
QUALITY-OF-LIFE
CARDIOVASCULAR-DISEASE
PHYSICAL-ACTIVITY
OLD-AGE
OBESITY
RISK
IMPACT
MORTALITY
FITNESS
3143 Nutrition
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Jyv_korpi_et_al._Associations....pdf 630.1Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record