Hyperoxia improves autonomic function in individuals with long-duration type 1 diabetes and macroalbuminuria

Show full item record



Permalink

http://hdl.handle.net/10138/329527

Citation

Laursen , J C , Hansen , C S , Bordino , M , Vistisen , D , Zobel , E H , Winther , S A , Groop , P-H , Frimodt-Møller , M , Bernardi , L & Rossing , P 2020 , ' Hyperoxia improves autonomic function in individuals with long-duration type 1 diabetes and macroalbuminuria ' , Diabetic Medicine , vol. 37 , no. 9 , pp. 1561-1568 . https://doi.org/10.1111/dme.14315

Title: Hyperoxia improves autonomic function in individuals with long-duration type 1 diabetes and macroalbuminuria
Author: Laursen, J.C.; Hansen, C.S.; Bordino, M.; Vistisen, D.; Zobel, E.H.; Winther, S.A.; Groop, P-H.; Frimodt-Møller, M.; Bernardi, L.; Rossing, P.
Contributor: University of Helsinki, HUS Abdominal Center
University of Helsinki, Department of Medical and Clinical Genetics
Date: 2020-09
Language: eng
Number of pages: 8
Belongs to series: Diabetic Medicine
ISSN: 0742-3071
URI: http://hdl.handle.net/10138/329527
Abstract: Abstract Aim Acute oxygen inhalation and slow deep breathing improve measures of autonomic function transiently in individuals with short-duration type 1 diabetes. Our aims were to examine these interventions and changes in autonomic function in individuals with long-duration type 1 diabetes and to explore interactions with the presence of macroalbuminuria or existing cardiovascular autonomic neuropathy. Methods Individuals with type 1 diabetes (n = 54) were exposed to acute oxygen inhalation, slow deep breathing and a combination of both (hereafter ?the combination?). Primary outcomes were change in baroreflex sensitivity and heart rate variability. Associations between changes in outcomes were evaluated using mixed effects models. Results Mean age ± sd was 60 ± 10 years and diabetes duration was 38 ± 14 years. Changes are presented as per cent difference from baseline with 95% confidence intervals. Acute oxygen inhalation, slow deep breathing and the combination increased baroreflex sensitivity by 21 (10, 34)%, 32 (13, 53)% and 30 (10, 54)%, respectively. Acute oxygen inhalation trended towards increasing heart rate variability 8 (?1, 17)% (P = 0.056), and slow deep breathing and the combination increased heart rate variability by 33 (18, 49)% and 44 (27, 64)% respectively. Macroalbuminuria or cardiovascular autonomic neuropathy did not modify results. Conclusion Autonomic function is improved transiently in individuals with long-duration type 1 diabetes and normoalbuminuria or macroalbuminuria by acute oxygen inhalation and slow deep breathing. There is a risk of survival bias. Autonomic dysfunction might be a reversible condition, and hypoxia might represent a target of intervention.
Subject: 3121 General medicine, internal medicine and other clinical medicine
NEUROPATHY
MORTALITY
DYSFUNCTION
RISK
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
dme.14315.pdf 827.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record