Chronotype in very low birth weight adults - a sibling study

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Björkqvist , J , Kuula , J , Kuula , L , Nurhonen , M , Hovi , P , Räikkönen , K , Pesonen , A & Kajantie , E 2020 , ' Chronotype in very low birth weight adults - a sibling study ' , Chronobiology International , vol. 37 , no. 7 , pp. 1023-1033 . https://doi.org/10.1080/07420528.2020.1754847

Title: Chronotype in very low birth weight adults - a sibling study
Author: Björkqvist, Johan; Kuula, Juho; Kuula, Liisa; Nurhonen, Markku; Hovi, Petteri; Räikkönen, Katri; Pesonen, Anu; Kajantie, Eero
Contributor: University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, SLEEPWELL Research Program
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, HUS Children and Adolescents
Date: 2020-07-02
Language: eng
Number of pages: 11
Belongs to series: Chronobiology International
ISSN: 0742-0528
URI: http://hdl.handle.net/10138/329528
Abstract: Chronotype is the temporal preference for activity and sleep during the 24 h day and is linked to mental and physical health, quality of life, and mortality. Later chronotypes, so-called “night owls”, consistently display poorer health outcomes than “larks”. Previous studies have suggested that preterm birth (<37 weeks of gestation) is associated with an earlier chronotype in children, adolescents, and young adults, but studies beyond this age are absent. Our aim was to determine if adults born preterm at very low birth weight (VLBW, ≤1500 g) display different chronotypes than their siblings. We studied VLBW adults, aged 29.9 years (SD 2.8), matched with same-sex term-born siblings as controls. A total of 123 participants, consisting of 53 sibling pairs and 17 unmatched participants, provided actigraphy-derived data on the timing, duration, and quality of sleep from 1640 nights (mean 13.3 per participant, SD 2.7). Mixed effects models provided estimates and significance tests. Compared to their siblings, VLBW adults displayed 27 min earlier sleep midpoint during free days (95% CI: 3 to 51 min, p =.029). This was also reflected in the timing of falling asleep, waking up, and sleep-debt corrected sleep midpoint. The findings were emphasized in VLBW participants born small for gestational age. VLBW adults displayed an earlier chronotype than their siblings still at age 30, which suggests that the earlier chronotype is an enduring individual trait not explained by shared family factors. This preference could provide protection from risks associated with preterm birth.
Subject: Actigraphy
sleep midpoint
midsleep
MSFsc
VLBW
very low birth weight
preterm
prematurity
PITUITARY-ADRENAL AXIS
QUALITY-OF-LIFE
YOUNG-ADULTS
CIRCADIAN PREFERENCE
PRETERM CHILDREN
PRENATAL STRESS
SLEEP
BORN
HELSINKI
RHYTHM
515 Psychology
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