Testosterone and specific symptoms of depression : Evidence from NHANES 2011–2016

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http://hdl.handle.net/10138/329623

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Määttänen , I , Gluschkoff , K , Komulainen , K , Airaksinen , J , Savelieva , K , Garcia-Velázquez , R & Jokela , M 2021 , ' Testosterone and specific symptoms of depression : Evidence from NHANES 2011–2016 ' , Comprehensive psychoneuroendocrinology , vol. 6 , 100044 . https://doi.org/10.1016/j.cpnec.2021.100044

Title: Testosterone and specific symptoms of depression : Evidence from NHANES 2011–2016
Author: Määttänen, Ilmari; Gluschkoff, Kia; Komulainen, Kaisla; Airaksinen, Jaakko; Savelieva, Kateryna; Garcia-Velázquez, Regina; Jokela, Markus
Contributor: University of Helsinki, Medicum
University of Helsinki, Medicum
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Institute of Criminology and Legal Policy
University of Helsinki, Helsinki Collegium for Advanced Studies
University of Helsinki, Department of Psychology and Logopedics
University of Helsinki, Behavioural Sciences
Date: 2021-05
Number of pages: 5
Belongs to series: Comprehensive psychoneuroendocrinology
ISSN: 2666-4976
URI: http://hdl.handle.net/10138/329623
Abstract: Testosterone is one possible biomarker for depression risk among men and women. Both high and low levels of testosterone have been associated with depression, at least among men. Testosterone may be associated only with specific symptoms of depression, which might help to explain inconsistencies in previous results. We examined the cross-sectional associations between total testosterone and the specific symptoms of depression using pooled data across three cycles of NHANES (2011–2012, 2013–2014, and 2015–2016). The sample included 4253 men and 5102 women. Testosterone was modelled as 1) a dichotomous (low testosterone cut-off <300 ​ng/dL for men and 15 ​ng/dL for women) and 2) a continuous variable using cubic splines. In men, very low testosterone was weakly associated with problems with appetite, whereas very high testosterone was associated with sleep problems and weakly associated with tiredness. There were no consistent symptom-specific associations among women. These findings provide only suggestive evidence for symptom-specific associations between testosterone and depression, mainly related to somatic complaints. Further data are needed to assess the reliability of these associations.
Subject: 515 Psychology
3142 Public health care science, environmental and occupational health
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