The Potential of Parsley Polyphenols and Their Antioxidant Capacity to Help in the Treatment of Depression and Anxiety : An In Vivo Subacute Study

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Es-safi , I , Mechchate , H , Amaghnouje , A , Kamaly , O M A , Jawhari , F Z , Imtara , H , Grafov , A & Bousta , D 2021 , ' The Potential of Parsley Polyphenols and Their Antioxidant Capacity to Help in the Treatment of Depression and Anxiety : An In Vivo Subacute Study ' , Molecules , vol. 26 , no. 7 , 2009 . https://doi.org/10.3390/molecules26072009

Title: The Potential of Parsley Polyphenols and Their Antioxidant Capacity to Help in the Treatment of Depression and Anxiety : An In Vivo Subacute Study
Author: Es-safi, Imane; Mechchate, Hamza; Amaghnouje, Amal; Kamaly, Omkulthom Mohamed Al; Jawhari, Fatima Zahra; Imtara, Hamada; Grafov, Andriy; Bousta, Dalila
Contributor organization: Department of Chemistry
Date: 2021-04
Language: eng
Number of pages: 12
Belongs to series: Molecules
ISSN: 1420-3049
DOI: https://doi.org/10.3390/molecules26072009
URI: http://hdl.handle.net/10138/329694
Abstract: Depression and anxiety are major mental health problems in all parts of the world. These illnesses are associated with a number of risk factors, including oxidative stress. Psychotropic drugs of a chemical nature have demonstrated several side effects that elevated the impact of those illnesses. Faced with this situation, natural products appear to be a promising alternative. The aim of this study was to evaluate the anxiolytic and antidepressant effects of the Petroselinum sativum polyphenols in vivo, as well as its correlated antioxidant properties in vitro. Anxiolytic activity of the extract (50 and 100 mg/kg) was evaluated using the open field and the light-dark chamber tests, while the antidepressant activity was evaluated using the forced swimming test. The antioxidant activity of the extract was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical test and the FRAP (iron-reducing capacity) test. The phenolic extract showed very powerful anxiolytic and antidepressant-like effects, especially at a dose of 100 mg/kg, decreasing the depressive behavior in mice (decreased immobility time) and also the anxiolytic behavior (tendency for discovery in the center and illuminated areas) better even than those of paroxetine and bromazepam (classic drugs) concomitant with those results the extract also showed an important antioxidant capacity. These preliminary results suggest that Petroselinum sativum exhibits anxiolytic and antidepressant potential for use as a complement or independent phytomedicine to treat depression and anxiety.
Subject: 116 Chemical sciences
Petroselinum sativum
polyphenol
anxiolytic
antidepressant-like
antioxidant
pharmacology
herbal medicine
natural products
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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