Engineering of primary carbon metabolism in filamentous fungi

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http://hdl.handle.net/10138/329755

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Chroumpi , T , Mäkelä , M & de Vries , R 2020 , ' Engineering of primary carbon metabolism in filamentous fungi ' , Biotechnology Advances , vol. 43 , 107551 . https://doi.org/10.1016/j.biotechadv.2020.107551

Title: Engineering of primary carbon metabolism in filamentous fungi
Author: Chroumpi, Tania; Mäkelä, Miia; de Vries, Ronald
Contributor: University of Helsinki, Department of Microbiology
Date: 2020-11
Language: eng
Number of pages: 23
Belongs to series: Biotechnology Advances
ISSN: 0734-9750
URI: http://hdl.handle.net/10138/329755
Abstract: Filamentous fungi are important industrial cell factories used for the production of a wide range of enzymes and metabolites. Their primary metabolism is a significant source of industrially important compounds, as well as of monomeric building blocks for the production of secondary metabolites and extracellular enzymes. Therefore, large efforts have been made towards the development of suitable strains for the industrial scale production of primary metabolites. Over the last decades, metabolic engineering of primary metabolism has become a powerful tool to enhance production of both primary and secondary metabolites. This review summarises the different metabolic engineering methods that have been applied to rationally improve the production of industrially relevant primary metabolites in filamentous fungi, and discusses related challenges and future perspectives.
Subject: 11832 Microbiology and virology
Filamentous fungi
metabolic engineering
primary metabolism
TCA cycle
Pentose catabolic pathway
D-galacturonic acid pathway
glycolysis
organic acids
genome-scale models
D-GALACTURONIC ACID
L-LACTIC ACID
XYLITOL DEHYDROGENASE GENE
YEAST YARROWIA-LIPOLYTICA
L-XYLULOSE REDUCTASE
D-XYLOSE REDUCTASE
L-ASCORBIC-ACID
ASPERGILLUS-NIGER
CITRIC-ACID
ITACONIC ACID
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