Positron emission tomography examination of cerebral blood flow and glucose metabolism in young CADASIL patients

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Tuominen , S , Miao , Q , Kurki , T , Tuisku , S , Pöyhönen , M , Kalimo , H , Viitanen , M , Sipila , H T , Bergman , J & Rinne , JO 2004 , ' Positron emission tomography examination of cerebral blood flow and glucose metabolism in young CADASIL patients ' , Stroke , vol. 35 , no. 5 , pp. 1063-1067 . https://doi.org/10.1161/01.STR.0000124124.69842.2d

Title: Positron emission tomography examination of cerebral blood flow and glucose metabolism in young CADASIL patients
Author: Tuominen, Susanna; Miao, Qing; Kurki, Timo; Tuisku, Seppo; Pöyhönen, Minna; Kalimo, Hannu; Viitanen, Matti; Sipila, Hannu T.; Bergman, Jörgen; Rinne, JO
Contributor organization: HUSLAB
Medicum
Department of Pathology
Date: 2004-05
Language: eng
Number of pages: 5
Belongs to series: Stroke
ISSN: 0039-2499
DOI: https://doi.org/10.1161/01.STR.0000124124.69842.2d
URI: http://hdl.handle.net/10138/329802
Abstract: Background and Purpose - CADASIL causes repeated ischemic strokes leading to subcortical vascular dementia. The purpose of this study was to assess whether cerebral blood flow (CBF) and regional cerebral metabolic rates of glucose (rCMR(gluc)) in CADASIL patients are affected in early adulthood. Methods - CBF and rCMR(gluc) were examined with positron emission tomography in correlation with magnetic resonance imaging (MRI) in 14 adult ( 19 to 41 years) CADASIL patients with the Notch3 R133C mutation. Seven patients had experienced transient ischemic attack and 3 had experienced greater than or equal to1 strokes. Results - The mean CBF in the CADASIL patients was significantly lower in both frontal (P = 0.019) and occipital (P = 0.009) white matter (WM) than those in the controls. CBF decreased significantly with increased severity of the disease. The patients had lower mean rCMR(gluc) values than the controls, although differences were not statistically significant. Sum scores of semiquantitative MRI rating scale (Scheltens) correlated significantly with WM CBF but not with rCMR(gluc). Conclusions - In CADASIL, there is an early and significant decrease in the CBF of WM associated with simultaneous MRI changes. These are obviously caused by the arteriopathy in long penetrating arteries and indicate early tissue damage, also expressed as impaired rCMR(gluc) in the WM.
Subject: AUTOSOMAL-DOMINANT ARTERIOPATHY
SUBCORTICAL INFARCTS
BRAIN
LEUKOENCEPHALOPATHY
LESIONS
HEMODYNAMICS
SPECTRUM
DEMENTIA
VOLUME
STROKE
3112 Neurosciences
3124 Neurology and psychiatry
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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