Ultrasonic actuation of a fine-needle improves biopsy yield

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Perra , E , Lampsijarvi , E , Barreto , G , Arif , M , Puranen , T , Haeggstrom , E , Pritzker , K P H & Nieminen , H J 2021 , ' Ultrasonic actuation of a fine-needle improves biopsy yield ' , Scientific Reports , vol. 11 , no. 1 , 8234 . https://doi.org/10.1038/s41598-021-87303-x

Title: Ultrasonic actuation of a fine-needle improves biopsy yield
Author: Perra, Emanuele; Lampsijarvi, Eetu; Barreto, Goncalo; Arif, Muhammad; Puranen, Tuomas; Haeggstrom, Edward; Pritzker, Kenneth P. H.; Nieminen, Heikki J.
Contributor organization: Department of Physics
HUS Internal Medicine and Rehabilitation
TRIMM - Translational Immunology Research Program
Date: 2021-04-15
Language: eng
Number of pages: 15
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-021-87303-x
URI: http://hdl.handle.net/10138/330162
Abstract: Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3-6x in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures.
Subject: 116 Chemical sciences
114 Physical sciences
RADIATION FORCE
DRUG
SIZE
DEFLECTION
COLLAPSE
TISSUE
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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