Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Show full item record



Permalink

http://hdl.handle.net/10138/330184

Citation

Surendran , P , Feofanova , E , Lahrouchi , N , Ntalla , I , Karthikeyan , S , Cook , J , Chen , L , Mifsud , B , Yao , C , Kraja , A T , Cartwright , J H , Hellwege , J N , Giri , A , Tragante , V , Thorleifsson , G , Liu , D J , Prins , B P , Stewart , I D , Cabrera , C P , Eales , J M , Akbarov , A , Auer , P L , Bielak , L F , Bis , J C , Braithwaite , V S , Brody , J A , Daw , E W , Warren , H R , Drenos , F , Nielsen , S F , Faul , J D , Fauman , E B , Fava , C , Ferreira , T , Foley , C N , Franceschini , N , Gao , H , Giannakopoulou , O , Giulianini , F , Gudbjartsson , D F , Guo , X , Harris , S E , Havulinna , A S , Helgadottir , A , Huffman , J E , Hwang , S-J , Kanoni , S , Kontto , J , Larson , M G , Li-Gao , R , Lindström , J , Lotta , L A , Lu , Y , Luan , J , Mahajan , A , Malerba , G , Masca , N G D , Mei , H , Menni , C , Mook-Kanamori , D O , Mosen-Ansorena , D , Muller-Nurasyid , M , Pare , G , Paul , D S , Perola , M , Poveda , A , Rauramaa , R , Richard , M , Richardson , T G , Sepulveda , N , Sim , X , Smith , A , Smith , J A , Staley , J R , Stanakova , A , Sulem , P , Theriault , S , Thorsteinsdottir , U , Trompet , S , Varga , T V , Edwards , D R V , Veronesi , G , Weiss , S , Willems , S M , Yao , J , Young , R , Yu , B , Zhang , W , Zhao , J-H , Zhao , W , Zhao , W , Evangelou , E , Aeschbacher , S , Asllanaj , E , Blankenberg , S , Bonnycastle , L L , Bork-Jensen , J , Brandslund , I , Braund , P S , Burgess , S , Cho , K , Christensen , C , Connell , J , de Mutsert , R , Dominiczak , A F , Dorr , M , Eiriksdottir , G , Farmaki , A-E , Gaziano , J M , Grarup , N , Grove , M L , Hallmans , G , Hansen , T , Have , C T , Heiss , G , Jorgensen , M E , Jousilahti , P , Kajantie , E , Kamat , M , Karajamaki , A , Karpe , F , Koistinen , H A , Kovesdy , C P , Kuulasmaa , K , Laatikainen , T , Lannfelt , L , Lee , I-T , Lee , W-J , Linneberg , A , Martin , L W , Moitry , M , Nadkarni , G , Neville , M J , Palmer , C N A , Papanicolaou , G J , Pedersen , O , Peters , J , Poulter , N , Rasheed , A , Rasmussen , K L , Rayner , N W , Magi , R , Renstrom , F , Rettig , R , Rossouw , J , Schreiner , P J , Sever , P S , Sigurdsson , E L , Skaaby , T , Sun , Y , Sundstrom , J , Thorgeirsson , G , Esko , T , Trabetti , E , Tsao , P S , Tuomi , T , Turner , S T , Tzoulaki , I , Vaartjes , I , Vergnaud , A-C , Willer , C J , Wilson , P W F , Witte , D R , Yonova-Doing , E , Zhang , H , Aliya , N , Almgren , P , Amouyel , P , Asselbergs , F W , Barnes , M R , Blakemore , A , Boehnke , M , Bots , M L , Bottinger , E P , Buring , J E , Chambers , J C , Chen , Y-D I , Chowdhury , R , Conen , D , Correa , A , Smith , G D , de Boer , R A , Deary , I J , Dedoussis , G , Deloukas , P , Di Angelantonio , E , Elliott , P , Felix , S B , Ferrieres , J , Ford , I , Fornage , M , Franks , P W , Franks , S , Frossard , P , Gambaro , G , Gaunt , T R , Groop , L , Gudnason , V , Harris , T B , Hayward , C , Hennig , B J , Herzig , K-H , Ingelsson , E , Tuomilehto , J , Jarvelin , M-R , Jukema , J W , Kardia , S L R , Kee , F , Kooner , J S , Kooperberg , C , Launer , L J , Lind , L , Loos , R J F , Majumder , A A S , Laakso , M , McCarthy , M , Melander , O , Mohlke , K L , Murray , A D , Nordestgaard , B G , Orho-Melander , M , Packard , C J , Padmanabhan , S , Palmas , W , Polasek , O , Porteous , D J , Prentice , A M , Province , M A , Relton , C L , Rice , K , Ridker , P M , Rolandsson , O , Rosendaal , F R , Rotter , J , Rudan , I , Salomaa , V , Samani , N J , Sattar , N , Sheu , W H-H , Smith , B H , Soranzo , N , Spector , T D , Starr , J M , Sebert , S , Taylor , K D , Lakka , T A , Timpson , N J , Tobin , M D , van der Harst , P , van der Meer , P , Ramachandran , V S , Verweij , N , Virtamo , J , Volker , U , Weir , D R , Zeggini , E , Charchar , F J , Wareham , N J , Langenberg , C , Tomaszewski , M , Butterworth , A S , Caulfield , M J , Danesh , J , Edwards , T L , Holm , H , Hung , A M , Lindgren , C M , Liu , C , Manning , A K , Morris , A P , Morrison , A C , O'Donnell , C J , Psaty , B M , Saleheen , D , Stefansson , K , Boerwinkle , E , Chasman , D , Levy , D , Newton-Cheh , C , Munroe , P B & Howson , J M M 2020 , ' Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals ' , Nature Genetics , vol. 52 , no. 12 . https://doi.org/10.1038/s41588-020-00713-x

Title: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Author: Surendran, Praveen; Feofanova, Elena; Lahrouchi, Najim; Ntalla, Ioanna; Karthikeyan, Savita; Cook, James; Chen, Lingyan; Mifsud, Borbala; Yao, Chen; Kraja, Aldi T.; Cartwright, James H.; Hellwege, Jacklyn N.; Giri, Ayush; Tragante, Vinicius; Thorleifsson, Gudmar; Liu, Dajiang J.; Prins, Bram P.; Stewart, Isobel D.; Cabrera, Claudia P.; Eales, James M.; Akbarov, Artur; Auer, Paul L.; Bielak, Lawrence F.; Bis, Joshua C.; Braithwaite, Vickie S.; Brody, Jennifer A.; Daw, E. Warwick; Warren, Helen R.; Drenos, Fotios; Nielsen, Sune Fallgaard; Faul, Jessica D.; Fauman, Eric B.; Fava, Cristiano; Ferreira, Teresa; Foley, Christopher N.; Franceschini, Nora; Gao, He; Giannakopoulou, Olga; Giulianini, Franco; Gudbjartsson, Daniel F.; Guo, Xiuqing; Harris, Sarah E.; Havulinna, Aki S.; Helgadottir, Anna; Huffman, Jennifer E.; Hwang, Shih-Jen; Kanoni, Stavroula; Kontto, Jukka; Larson, Martin G.; Li-Gao, Ruifang; Lindström, Jaana; Lotta, Luca A.; Lu, Yingchang; Luan, Jian'an; Mahajan, Anubha; Malerba, Giovanni; Masca, Nicholas G. D.; Mei, Hao; Menni, Cristina; Mook-Kanamori, Dennis O.; Mosen-Ansorena, David; Muller-Nurasyid, Martina; Pare, Guillaume; Paul, Dirk S.; Perola, Markus; Poveda, Alaitz; Rauramaa, Rainer; Richard, Melissa; Richardson, Tom G.; Sepulveda, Nuno; Sim, Xueling; Smith, Albert; Smith, Jennifer A.; Staley, James R.; Stanakova, Alena; Sulem, Patrick; Theriault, Sebastien; Thorsteinsdottir, Unnur; Trompet, Stella; Varga, Tibor V.; Edwards, Digna R. Velez; Veronesi, Giovanni; Weiss, Stefan; Willems, Sara M.; Yao, Jie; Young, Robin; Yu, Bing; Zhang, Weihua; Zhao, Jing-Hua; Zhao, Wei; Zhao, Wei; Evangelou, Evangelos; Aeschbacher, Stefanie; Asllanaj, Eralda; Blankenberg, Stefan; Bonnycastle, Lori L.; Bork-Jensen, Jette; Brandslund, Ivan; Braund, Peter S.; Burgess, Stephen; Cho, Kelly; Christensen, Cramer; Connell, John; de Mutsert, Renee; Dominiczak, Anna F.; Dorr, Marcus; Eiriksdottir, Gudny; Farmaki, Aliki-Eleni; Gaziano, J. Michael; Grarup, Niels; Grove, Megan L.; Hallmans, Goran; Hansen, Torben; Have, Christian T.; Heiss, Gerardo; Jorgensen, Marit E.; Jousilahti, Pekka; Kajantie, Eero; Kamat, Mihir; Karajamaki, AnneMari; Karpe, Fredrik; Koistinen, Heikki A.; Kovesdy, Csaba P.; Kuulasmaa, Kari; Laatikainen, Tiina; Lannfelt, Lars; Lee, I-Te; Lee, Wen-Jane; Linneberg, Allan; Martin, Lisa W.; Moitry, Marie; Nadkarni, Girish; Neville, Matt J.; Palmer, Colin N. A.; Papanicolaou, George J.; Pedersen, Oluf; Peters, James; Poulter, Neil; Rasheed, Asif; Rasmussen, Katrine L.; Rayner, N. William; Magi, Reedik; Renstrom, Frida; Rettig, Rainer; Rossouw, Jacques; Schreiner, Pamela J.; Sever, Peter S.; Sigurdsson, Emil L.; Skaaby, Tea; Sun, Yan; Sundstrom, Johan; Thorgeirsson, Gudmundur; Esko, Tonu; Trabetti, Elisabetta; Tsao, Philip S.; Tuomi, Tiinamaija; Turner, Stephen T.; Tzoulaki, Ioanna; Vaartjes, Ilonca; Vergnaud, Anne-Claire; Willer, Cristen J.; Wilson, Peter W. F.; Witte, Daniel R.; Yonova-Doing, Ekaterina; Zhang, He; Aliya, Naheed; Almgren, Peter; Amouyel, Philippe; Asselbergs, Folkert W.; Barnes, Michael R.; Blakemore, Alexandra; Boehnke, Michael; Bots, Michiel L.; Bottinger, Erwin P.; Buring, Julie E.; Chambers, John C.; Chen, Yii-Der Ida; Chowdhury, Rajiv; Conen, David; Correa, Adolfo; Smith, George Davey; de Boer, Rudolf A.; Deary, Ian J.; Dedoussis, George; Deloukas, Panos; Di Angelantonio, Emanuele; Elliott, Paul; Felix, Stephan B.; Ferrieres, Jean; Ford, Ian; Fornage, Myriam; Franks, Paul W.; Franks, Stephen; Frossard, Philippe; Gambaro, Giovanni; Gaunt, Tom R.; Groop, Leif; Gudnason, Vilmundur; Harris, Tamara B.; Hayward, Caroline; Hennig, Branwen J.; Herzig, Karl-Heinz; Ingelsson, Erik; Tuomilehto, Jaakko; Jarvelin, Marjo-Riitta; Jukema, J. Wouter; Kardia, Sharon L. R.; Kee, Frank; Kooner, Jaspal S.; Kooperberg, Charles; Launer, Lenore J.; Lind, Lars; Loos, Ruth J. F.; Majumder, Abdulla Al Shafi; Laakso, Markku; McCarthy, Mark; Melander, Olle; Mohlke, Karen L.; Murray, Alison D.; Nordestgaard, Borge Gronne; Orho-Melander, Marju; Packard, Chris J.; Padmanabhan, Sandosh; Palmas, Walter; Polasek, Ozren; Porteous, David J.; Prentice, Andrew M.; Province, Michael A.; Relton, Caroline L.; Rice, Kenneth; Ridker, Paul M.; Rolandsson, Olov; Rosendaal, Frits R.; Rotter, Jerome; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J.; Sattar, Naveed; Sheu, Wayne H-H; Smith, Blair H.; Soranzo, Nicole; Spector, Timothy D.; Starr, John M.; Sebert, Sylvain; Taylor, Kent D.; Lakka, Timo A.; Timpson, Nicholas J.; Tobin, Martin D.; van der Harst, Pim; van der Meer, Peter; Ramachandran, Vasan S.; Verweij, Niek; Virtamo, Jarmo; Volker, Uwe; Weir, David R.; Zeggini, Eleftheria; Charchar, Fadi J.; Wareham, Nicholas J.; Langenberg, Claudia; Tomaszewski, Maciej; Butterworth, Adam S.; Caulfield, Mark J.; Danesh, John; Edwards, Todd L.; Holm, Hilma; Hung, Adriana M.; Lindgren, Cecilia M.; Liu, Chunyu; Manning, Alisa K.; Morris, Andrew P.; Morrison, Alanna C.; O'Donnell, Christopher J.; Psaty, Bruce M.; Saleheen, Danish; Stefansson, Kari; Boerwinkle, Eric; Chasman, Daniel; Levy, Daniel; Newton-Cheh, Christopher; Munroe, Patricia B.; Howson, Joanna M. M.
Contributor: University of Helsinki, Complex Disease Genetics
University of Helsinki, Research Programs Unit
University of Helsinki, HUS Children and Adolescents
University of Helsinki, HUS Internal Medicine and Rehabilitation
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Centre of Excellence in Complex Disease Genetics
University of Helsinki, Clinicum
Date: 2020-12
Language: eng
Number of pages: 30
Belongs to series: Nature Genetics
ISSN: 1061-4036
URI: http://hdl.handle.net/10138/330184
Abstract: Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency
Subject: GENOME-WIDE ASSOCIATION
MENDELIAN RANDOMIZATION
COMMON VARIANTS
IDENTIFIES COMMON
LOCI
RISK
FREQUENCY
TRAITS
HYPERTENSION
GENETICS
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Rights:
Full text embargoed until: 2021-05-23


Files in this item

Files Size Format View

Embargo on files ends: 2021-05-23

This item appears in the following Collection(s)

Show full item record