Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

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Surendran , P , Feofanova , E , Lahrouchi , N , Ntalla , I , Karthikeyan , S , Cook , J , Chen , L , Mifsud , B , Yao , C , Kraja , A T , Cartwright , J H , Hellwege , J N , Giri , A , Tragante , V , Thorleifsson , G , Liu , D J , Prins , B P , Stewart , I D , Cabrera , C P , Eales , J M , Akbarov , A , Auer , P L , Bielak , L F , Bis , J C , Braithwaite , V S , Brody , J A , Daw , E W , Warren , H R , Drenos , F , Nielsen , S F , Faul , J D , Fauman , E B , Fava , C , Ferreira , T , Foley , C N , Franceschini , N , Gao , H , Giannakopoulou , O , Giulianini , F , Gudbjartsson , D F , Guo , X , Harris , S E , Havulinna , A S , Helgadottir , A , Huffman , J E , Hwang , S-J , Kanoni , S , Kontto , J , Larson , M G , Li-Gao , R , Lindström , J , Lotta , L A , Lu , Y , Luan , J , Mahajan , A , Malerba , G , Masca , N G D , Mei , H , Menni , C , Mook-Kanamori , D O , Mosen-Ansorena , D , Muller-Nurasyid , M , Pare , G , Paul , D S , Perola , M , Poveda , A , Rauramaa , R , Richard , M , Richardson , T G , Sepulveda , N , Sim , X , Smith , A , Smith , J A , Staley , J R , Stanakova , A , Sulem , P , Theriault , S , Thorsteinsdottir , U , Trompet , S , Varga , T V , Edwards , D R V , Veronesi , G , Weiss , S , Willems , S M , Yao , J , Young , R , Yu , B , Zhang , W , Zhao , J-H , Zhao , W , Zhao , W , Evangelou , E , Aeschbacher , S , Asllanaj , E , Blankenberg , S , Bonnycastle , L L , Bork-Jensen , J , Brandslund , I , Braund , P S , Burgess , S , Cho , K , Christensen , C , Connell , J , de Mutsert , R , Dominiczak , A F , Dorr , M , Eiriksdottir , G , Farmaki , A-E , Gaziano , J M , Grarup , N , Grove , M L , Hallmans , G , Hansen , T , Have , C T , Heiss , G , Jorgensen , M E , Jousilahti , P , Kajantie , E , Kamat , M , Karajamaki , A , Karpe , F , Koistinen , H A , Kovesdy , C P , Kuulasmaa , K , Laatikainen , T , Lannfelt , L , Lee , I-T , Lee , W-J , Linneberg , A , Martin , L W , Moitry , M , Nadkarni , G , Neville , M J , Palmer , C N A , Papanicolaou , G J , Pedersen , O , Peters , J , Poulter , N , Rasheed , A , Rasmussen , K L , Rayner , N W , Magi , R , Renstrom , F , Rettig , R , Rossouw , J , Schreiner , P J , Sever , P S , Sigurdsson , E L , Skaaby , T , Sun , Y , Sundstrom , J , Thorgeirsson , G , Esko , T , Trabetti , E , Tsao , P S , Tuomi , T , Turner , S T , Tzoulaki , I , Vaartjes , I , Vergnaud , A-C , Willer , C J , Wilson , P W F , Witte , D R , Yonova-Doing , E , Zhang , H , Aliya , N , Almgren , P , Amouyel , P , Asselbergs , F W , Barnes , M R , Blakemore , A , Boehnke , M , Bots , M L , Bottinger , E P , Buring , J E , Chambers , J C , Chen , Y-D I , Chowdhury , R , Conen , D , Correa , A , Smith , G D , de Boer , R A , Deary , I J , Dedoussis , G , Deloukas , P , Di Angelantonio , E , Elliott , P , Felix , S B , Ferrieres , J , Ford , I , Fornage , M , Franks , P W , Franks , S , Frossard , P , Gambaro , G , Gaunt , T R , Groop , L , Gudnason , V , Harris , T B , Hayward , C , Hennig , B J , Herzig , K-H , Ingelsson , E , Tuomilehto , J , Jarvelin , M-R , Jukema , J W , Kardia , S L R , Kee , F , Kooner , J S , Kooperberg , C , Launer , L J , Lind , L , Loos , R J F , Majumder , A A S , Laakso , M , McCarthy , M , Melander , O , Mohlke , K L , Murray , A D , Nordestgaard , B G , Orho-Melander , M , Packard , C J , Padmanabhan , S , Palmas , W , Polasek , O , Porteous , D J , Prentice , A M , Province , M A , Relton , C L , Rice , K , Ridker , P M , Rolandsson , O , Rosendaal , F R , Rotter , J , Rudan , I , Salomaa , V , Samani , N J , Sattar , N , Sheu , W H-H , Smith , B H , Soranzo , N , Spector , T D , Starr , J M , Sebert , S , Taylor , K D , Lakka , T A , Timpson , N J , Tobin , M D , van der Harst , P , van der Meer , P , Ramachandran , V S , Verweij , N , Virtamo , J , Volker , U , Weir , D R , Zeggini , E , Charchar , F J , Wareham , N J , Langenberg , C , Tomaszewski , M , Butterworth , A S , Caulfield , M J , Danesh , J , Edwards , T L , Holm , H , Hung , A M , Lindgren , C M , Liu , C , Manning , A K , Morris , A P , Morrison , A C , O'Donnell , C J , Psaty , B M , Saleheen , D , Stefansson , K , Boerwinkle , E , Chasman , D , Levy , D , Newton-Cheh , C , Munroe , P B & Howson , J M M 2020 , ' Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals ' , Nature Genetics , vol. 52 , no. 12 . https://doi.org/10.1038/s41588-020-00713-x

Title: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Author: Surendran, Praveen; Feofanova, Elena; Lahrouchi, Najim; Ntalla, Ioanna; Karthikeyan, Savita; Cook, James; Chen, Lingyan; Mifsud, Borbala; Yao, Chen; Kraja, Aldi T.; Cartwright, James H.; Hellwege, Jacklyn N.; Giri, Ayush; Tragante, Vinicius; Thorleifsson, Gudmar; Liu, Dajiang J.; Prins, Bram P.; Stewart, Isobel D.; Cabrera, Claudia P.; Eales, James M.; Akbarov, Artur; Auer, Paul L.; Bielak, Lawrence F.; Bis, Joshua C.; Braithwaite, Vickie S.; Brody, Jennifer A.; Daw, E. Warwick; Warren, Helen R.; Drenos, Fotios; Nielsen, Sune Fallgaard; Faul, Jessica D.; Fauman, Eric B.; Fava, Cristiano; Ferreira, Teresa; Foley, Christopher N.; Franceschini, Nora; Gao, He; Giannakopoulou, Olga; Giulianini, Franco; Gudbjartsson, Daniel F.; Guo, Xiuqing; Harris, Sarah E.; Havulinna, Aki S.; Helgadottir, Anna; Huffman, Jennifer E.; Hwang, Shih-Jen; Kanoni, Stavroula; Kontto, Jukka; Larson, Martin G.; Li-Gao, Ruifang; Lindström, Jaana; Lotta, Luca A.; Lu, Yingchang; Luan, Jian'an; Mahajan, Anubha; Malerba, Giovanni; Masca, Nicholas G. D.; Mei, Hao; Menni, Cristina; Mook-Kanamori, Dennis O.; Mosen-Ansorena, David; Muller-Nurasyid, Martina; Pare, Guillaume; Paul, Dirk S.; Perola, Markus; Poveda, Alaitz; Rauramaa, Rainer; Richard, Melissa; Richardson, Tom G.; Sepulveda, Nuno; Sim, Xueling; Smith, Albert; Smith, Jennifer A.; Staley, James R.; Stanakova, Alena; Sulem, Patrick; Theriault, Sebastien; Thorsteinsdottir, Unnur; Trompet, Stella; Varga, Tibor V.; Edwards, Digna R. Velez; Veronesi, Giovanni; Weiss, Stefan; Willems, Sara M.; Yao, Jie; Young, Robin; Yu, Bing; Zhang, Weihua; Zhao, Jing-Hua; Zhao, Wei; Zhao, Wei; Evangelou, Evangelos; Aeschbacher, Stefanie; Asllanaj, Eralda; Blankenberg, Stefan; Bonnycastle, Lori L.; Bork-Jensen, Jette; Brandslund, Ivan; Braund, Peter S.; Burgess, Stephen; Cho, Kelly; Christensen, Cramer; Connell, John; de Mutsert, Renee; Dominiczak, Anna F.; Dorr, Marcus; Eiriksdottir, Gudny; Farmaki, Aliki-Eleni; Gaziano, J. Michael; Grarup, Niels; Grove, Megan L.; Hallmans, Goran; Hansen, Torben; Have, Christian T.; Heiss, Gerardo; Jorgensen, Marit E.; Jousilahti, Pekka; Kajantie, Eero; Kamat, Mihir; Karajamaki, AnneMari; Karpe, Fredrik; Koistinen, Heikki A.; Kovesdy, Csaba P.; Kuulasmaa, Kari; Laatikainen, Tiina; Lannfelt, Lars; Lee, I-Te; Lee, Wen-Jane; Linneberg, Allan; Martin, Lisa W.; Moitry, Marie; Nadkarni, Girish; Neville, Matt J.; Palmer, Colin N. A.; Papanicolaou, George J.; Pedersen, Oluf; Peters, James; Poulter, Neil; Rasheed, Asif; Rasmussen, Katrine L.; Rayner, N. William; Magi, Reedik; Renstrom, Frida; Rettig, Rainer; Rossouw, Jacques; Schreiner, Pamela J.; Sever, Peter S.; Sigurdsson, Emil L.; Skaaby, Tea; Sun, Yan; Sundstrom, Johan; Thorgeirsson, Gudmundur; Esko, Tonu; Trabetti, Elisabetta; Tsao, Philip S.; Tuomi, Tiinamaija; Turner, Stephen T.; Tzoulaki, Ioanna; Vaartjes, Ilonca; Vergnaud, Anne-Claire; Willer, Cristen J.; Wilson, Peter W. F.; Witte, Daniel R.; Yonova-Doing, Ekaterina; Zhang, He; Aliya, Naheed; Almgren, Peter; Amouyel, Philippe; Asselbergs, Folkert W.; Barnes, Michael R.; Blakemore, Alexandra; Boehnke, Michael; Bots, Michiel L.; Bottinger, Erwin P.; Buring, Julie E.; Chambers, John C.; Chen, Yii-Der Ida; Chowdhury, Rajiv; Conen, David; Correa, Adolfo; Smith, George Davey; de Boer, Rudolf A.; Deary, Ian J.; Dedoussis, George; Deloukas, Panos; Di Angelantonio, Emanuele; Elliott, Paul; Felix, Stephan B.; Ferrieres, Jean; Ford, Ian; Fornage, Myriam; Franks, Paul W.; Franks, Stephen; Frossard, Philippe; Gambaro, Giovanni; Gaunt, Tom R.; Groop, Leif; Gudnason, Vilmundur; Harris, Tamara B.; Hayward, Caroline; Hennig, Branwen J.; Herzig, Karl-Heinz; Ingelsson, Erik; Tuomilehto, Jaakko; Jarvelin, Marjo-Riitta; Jukema, J. Wouter; Kardia, Sharon L. R.; Kee, Frank; Kooner, Jaspal S.; Kooperberg, Charles; Launer, Lenore J.; Lind, Lars; Loos, Ruth J. F.; Majumder, Abdulla Al Shafi; Laakso, Markku; McCarthy, Mark; Melander, Olle; Mohlke, Karen L.; Murray, Alison D.; Nordestgaard, Borge Gronne; Orho-Melander, Marju; Packard, Chris J.; Padmanabhan, Sandosh; Palmas, Walter; Polasek, Ozren; Porteous, David J.; Prentice, Andrew M.; Province, Michael A.; Relton, Caroline L.; Rice, Kenneth; Ridker, Paul M.; Rolandsson, Olov; Rosendaal, Frits R.; Rotter, Jerome; Rudan, Igor; Salomaa, Veikko; Samani, Nilesh J.; Sattar, Naveed; Sheu, Wayne H-H; Smith, Blair H.; Soranzo, Nicole; Spector, Timothy D.; Starr, John M.; Sebert, Sylvain; Taylor, Kent D.; Lakka, Timo A.; Timpson, Nicholas J.; Tobin, Martin D.; van der Harst, Pim; van der Meer, Peter; Ramachandran, Vasan S.; Verweij, Niek; Virtamo, Jarmo; Volker, Uwe; Weir, David R.; Zeggini, Eleftheria; Charchar, Fadi J.; Wareham, Nicholas J.; Langenberg, Claudia; Tomaszewski, Maciej; Butterworth, Adam S.; Caulfield, Mark J.; Danesh, John; Edwards, Todd L.; Holm, Hilma; Hung, Adriana M.; Lindgren, Cecilia M.; Liu, Chunyu; Manning, Alisa K.; Morris, Andrew P.; Morrison, Alanna C.; O'Donnell, Christopher J.; Psaty, Bruce M.; Saleheen, Danish; Stefansson, Kari; Boerwinkle, Eric; Chasman, Daniel; Levy, Daniel; Newton-Cheh, Christopher; Munroe, Patricia B.; Howson, Joanna M. M.
Contributor organization: Complex Disease Genetics
Research Programs Unit
CAMM - Research Program for Clinical and Molecular Metabolism
Faculty of Medicine
University of Helsinki
HUS Children and Adolescents
Lastentautien yksikkö
Clinicum
Children's Hospital
Helsinki University Hospital Area
HUS Internal Medicine and Rehabilitation
Department of Medicine
Department of Biochemistry and Developmental Biology
Centre of Excellence in Complex Disease Genetics
HUS Abdominal Center
Institute for Molecular Medicine Finland
Endokrinologian yksikkö
Department of Public Health
Date: 2020-12
Language: eng
Number of pages: 30
Belongs to series: Nature Genetics
ISSN: 1061-4036
DOI: https://doi.org/10.1038/s41588-020-00713-x
URI: http://hdl.handle.net/10138/330184
Abstract: Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency
Subject: GENOME-WIDE ASSOCIATION
MENDELIAN RANDOMIZATION
COMMON VARIANTS
IDENTIFIES COMMON
LOCI
RISK
FREQUENCY
TRAITS
HYPERTENSION
GENETICS
3111 Biomedicine
1184 Genetics, developmental biology, physiology
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: acceptedVersion


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