Ketone body 3-hydroxybutyrate as a biomarker of aggression

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Whipp , A M , Vuoksimaa , E , Korhonen , T , Pool , R , But , A , Ligthart , L , Hagenbeek , F A , Bartels , M , Bogl , L H , Pulkkinen , L , Rose , R J , Boomsma , D & Kaprio , J 2021 , ' Ketone body 3-hydroxybutyrate as a biomarker of aggression ' , Scientific Reports , vol. 11 , no. 1 , 5813 . https://doi.org/10.1038/s41598-021-84635-6

Title: Ketone body 3-hydroxybutyrate as a biomarker of aggression
Author: Whipp, A. M.; Vuoksimaa, E.; Korhonen, T.; Pool, R.; But, A.; Ligthart, L.; Hagenbeek, F. A.; Bartels, M.; Bogl, L. H.; Pulkkinen, L.; Rose, R. J.; Boomsma, D.; Kaprio, J.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Public Health
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2021-03-12
Language: eng
Number of pages: 10
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/330201
Abstract: Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight metabolites (amino acids, ketone bodies), processed using H-1 nuclear magnetic resonance spectroscopy. We used a discovery sample of young adults and an independent adult replication sample. We studied 725 young adults from a population-based Finnish twin cohort born 1983-1987, with aggression levels rated in adolescence (ages 12, 14, 17) by multiple raters and blood plasma samples at age 22. Linear regression models specified metabolites as the response variable and aggression ratings as predictor variables, and included several potential confounders. All metabolites showed low correlations with aggression, with only one-3-hydroxybutyrate, a ketone body produced during fasting-showing significant (negative) associations with aggression. Effect sizes for different raters were generally similar in magnitude, while teacher-rated (age 12) and self-rated (age 14) aggression were both significant predictors of 3-hydroxybutyrate in multi-rater models. In an independent replication sample of 960 adults from the Netherlands Twin Register, higher aggression (self-rated) was also related to lower levels of 3-hydroxybutyrate. These exploratory epidemiologic results warrant further studies on the role of ketone metabolism in aggression.
Subject: 3111 Biomedicine
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