Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections

Show full item record



Permalink

http://hdl.handle.net/10138/330202

Citation

Mohanraj , U , Jokinen , M , Rayamajhi Thapa , R , Paloniemi , M , Vesikari , T , Lappalainen , M , Tarkka , E , Nora-Krukle , Z , Vilmane , A , Vettenranta , K , Mangani , C , Oikarinen , S , Fan , Y-M , Ashorn , P , Väisänen , E & Söderlund-Venermo , M 2021 , ' Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections ' , Viruses-Basel , vol. 13 , no. 3 , 483 . https://doi.org/10.3390/v13030483

Title: Human Protoparvovirus DNA and IgG in Children and Adults with and without Respiratory or Gastrointestinal Infections
Author: Mohanraj, Ushanandini; Jokinen, Maija; Rayamajhi Thapa, Rajita; Paloniemi, Minna; Vesikari, Timo; Lappalainen, Maija; Tarkka, Eveliina; Nora-Krukle, Zaiga; Vilmane, Anda; Vettenranta, Kim; Mangani, Charles; Oikarinen, Sami; Fan, Yue-Mei; Ashorn, Per; Väisänen, Elina; Söderlund-Venermo, Maria
Contributor: University of Helsinki, Human Parvoviruses: Epidemiology, Molecular Biology and Clinical Impact
University of Helsinki, Department of Virology
University of Helsinki, Department of Virology
University of Helsinki, HUSLAB
University of Helsinki, HUSLAB
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Department of Virology
University of Helsinki, Human Parvoviruses: Epidemiology, Molecular Biology and Clinical Impact
Date: 2021
Language: eng
Number of pages: 13
Belongs to series: Viruses-Basel
ISSN: 1999-4915
URI: http://hdl.handle.net/10138/330202
Abstract: Abstract: Three human protoparvoviruses, bufavirus (BuV), tusavirus (TuV) and cutavirus (CuV), have recently been discovered in diarrheal stool. BuV has been associated with diarrhea and CuV with cutaneous T-cell lymphoma, but there are hardly any data for TuV or CuV in stool or respiratory samples. Hence, using qPCR and IgG enzyme immunoassays, we analyzed 1072 stool, 316 respiratory and 445 serum or plasma samples from 1098 patients with and without gastroenteritis (GE) or respiratory-tract infections (RTI) from Finland, Latvia and Malawi. The overall CuV-DNA prevalences in stool samples ranged between 0–6.1% among our six patient cohorts. In Finland, CuV DNA was significantly more prevalent in GE patients above rather than below 60 years of age (5.1% vs 0.2%). CuV DNA was more prevalent in stools among Latvian and Malawian children compared with Finnish children. In 10/11 CuV DNA-positive adults and 4/6 CuV DNA-positive children with GE, no known causal pathogens were detected. Interestingly, for the first time, CuV DNA was observed in two nasopharyngeal aspirates from children with RTI and the rare TuV in diarrheal stools of two adults. Our results provide new insights on the occurrence of human protoparvoviruses in GE and RTI in different countries.
Subject: 11832 Microbiology and virology
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
viruses_13_00483_v2.pdf 983.8Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record