Elevated rates of horizontal gene transfer in the industrialized human microbiome

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Groussin , M , Poyet , M , Sistiaga , A , Kearney , S M , Moniz , K , Noel , M , Hooker , J , Gibbons , S M , Segurel , L , Froment , A , Mohamed , R S , Fezeu , A , Juimo , V A , Lafosse , S , Tabe , F E , Girard , C , Iqaluk , D , Nguyen , L T T , Shapiro , B J , Lehtimaki , J , Ruokolainen , L , Kettunen , P P , Vatanen , T , Sigwazi , S , Mabulla , A , Dominguez-Rodrigo , M , Nartey , Y A , Agyei-Nkansah , A , Duah , A , Awuku , Y A , Valles , K A , Asibey , S O , Afihene , M Y , Roberts , L R , Plymoth , A , Onyekwere , C A , Summons , R E , Xavier , R J & Alm , E J 2021 , ' Elevated rates of horizontal gene transfer in the industrialized human microbiome ' , Cell , vol. 184 , no. 8 , pp. 2053-2067 . https://doi.org/10.1016/j.cell.2021.02.052

Title: Elevated rates of horizontal gene transfer in the industrialized human microbiome
Author: Groussin, Mathieu; Poyet, Mathilde; Sistiaga, Ainara; Kearney, Sean M.; Moniz, Katya; Noel, Mary; Hooker, Jeff; Gibbons, Sean M.; Segurel, Laure; Froment, Alain; Mohamed, Rihlat Said; Fezeu, Alain; Juimo, Vanessa A.; Lafosse, Sophie; Tabe, Francis E.; Girard, Catherine; Iqaluk, Deborah; Nguyen, Le Thanh Tu; Shapiro, B. Jesse; Lehtimaki, Jenni; Ruokolainen, Lasse; Kettunen, Pinja P.; Vatanen, Tommi; Sigwazi, Shani; Mabulla, Audax; Dominguez-Rodrigo, Manuel; Nartey, Yvonne A.; Agyei-Nkansah, Adwoa; Duah, Amoako; Awuku, Yaw A.; Valles, Kenneth A.; Asibey, Shadrack O.; Afihene, Mary Y.; Roberts, Lewis R.; Plymoth, Amelie; Onyekwere, Charles A.; Summons, Roger E.; Xavier, Ramnik J.; Alm, Eric J.
Contributor organization: Centre of Excellence in Metapopulation Research
Helsinki Institute of Sustainability Science (HELSUS)
Veijo Kaitala / Principal Investigator
Faculty of Biological and Environmental Sciences
Neuroscience Center
Date: 2021-04-15
Language: eng
Number of pages: 33
Belongs to series: Cell
ISSN: 0092-8674
DOI: https://doi.org/10.1016/j.cell.2021.02.052
URI: http://hdl.handle.net/10138/330248
Abstract: Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. Here, we investigate the extent to which the rates and targets of horizontal gene transfer (HGT) vary across thousands of bacterial strains from 15 human populations spanning a range of industrialization. We show that HGTs have accumulated in the microbiome over recent host generations and that HGT occurs at high frequency within individuals. Comparison across human populations reveals that industrialized lifestyles are associated with higher HGT rates and that the functions of HGTs are related to the level of host industrialization. Our results suggest that gut bacteria continuously acquire new functionality based on host lifestyle and that high rates of HGT may be a recent development in human history linked to industrialization.
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: publishedVersion

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