Elevated rates of horizontal gene transfer in the industrialized human microbiome

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dc.contributor.author Groussin, Mathieu
dc.contributor.author Poyet, Mathilde
dc.contributor.author Sistiaga, Ainara
dc.contributor.author Kearney, Sean M.
dc.contributor.author Moniz, Katya
dc.contributor.author Noel, Mary
dc.contributor.author Hooker, Jeff
dc.contributor.author Gibbons, Sean M.
dc.contributor.author Segurel, Laure
dc.contributor.author Froment, Alain
dc.contributor.author Mohamed, Rihlat Said
dc.contributor.author Fezeu, Alain
dc.contributor.author Juimo, Vanessa A.
dc.contributor.author Lafosse, Sophie
dc.contributor.author Tabe, Francis E.
dc.contributor.author Girard, Catherine
dc.contributor.author Iqaluk, Deborah
dc.contributor.author Nguyen, Le Thanh Tu
dc.contributor.author Shapiro, B. Jesse
dc.contributor.author Lehtimaki, Jenni
dc.contributor.author Ruokolainen, Lasse
dc.contributor.author Kettunen, Pinja P.
dc.contributor.author Vatanen, Tommi
dc.contributor.author Sigwazi, Shani
dc.contributor.author Mabulla, Audax
dc.contributor.author Dominguez-Rodrigo, Manuel
dc.contributor.author Nartey, Yvonne A.
dc.contributor.author Agyei-Nkansah, Adwoa
dc.contributor.author Duah, Amoako
dc.contributor.author Awuku, Yaw A.
dc.contributor.author Valles, Kenneth A.
dc.contributor.author Asibey, Shadrack O.
dc.contributor.author Afihene, Mary Y.
dc.contributor.author Roberts, Lewis R.
dc.contributor.author Plymoth, Amelie
dc.contributor.author Onyekwere, Charles A.
dc.contributor.author Summons, Roger E.
dc.contributor.author Xavier, Ramnik J.
dc.contributor.author Alm, Eric J.
dc.date.accessioned 2021-05-25T06:30:03Z
dc.date.available 2021-05-25T06:30:03Z
dc.date.issued 2021-04-15
dc.identifier.citation Groussin , M , Poyet , M , Sistiaga , A , Kearney , S M , Moniz , K , Noel , M , Hooker , J , Gibbons , S M , Segurel , L , Froment , A , Mohamed , R S , Fezeu , A , Juimo , V A , Lafosse , S , Tabe , F E , Girard , C , Iqaluk , D , Nguyen , L T T , Shapiro , B J , Lehtimaki , J , Ruokolainen , L , Kettunen , P P , Vatanen , T , Sigwazi , S , Mabulla , A , Dominguez-Rodrigo , M , Nartey , Y A , Agyei-Nkansah , A , Duah , A , Awuku , Y A , Valles , K A , Asibey , S O , Afihene , M Y , Roberts , L R , Plymoth , A , Onyekwere , C A , Summons , R E , Xavier , R J & Alm , E J 2021 , ' Elevated rates of horizontal gene transfer in the industrialized human microbiome ' , Cell , vol. 184 , no. 8 , pp. 2053-2067 . https://doi.org/10.1016/j.cell.2021.02.052
dc.identifier.other PURE: 164014432
dc.identifier.other PURE UUID: 28c132fc-7109-45a3-a4f0-b55fa3403657
dc.identifier.other WOS: 000640387300016
dc.identifier.other ORCID: /0000-0003-0951-9100/work/94443657
dc.identifier.other ORCID: /0000-0001-7220-1985/work/94443786
dc.identifier.other ORCID: /0000-0002-3119-4499/work/94444118
dc.identifier.uri http://hdl.handle.net/10138/330248
dc.description.abstract Industrialization has impacted the human gut ecosystem, resulting in altered microbiome composition and diversity. Whether bacterial genomes may also adapt to the industrialization of their host populations remains largely unexplored. Here, we investigate the extent to which the rates and targets of horizontal gene transfer (HGT) vary across thousands of bacterial strains from 15 human populations spanning a range of industrialization. We show that HGTs have accumulated in the microbiome over recent host generations and that HGT occurs at high frequency within individuals. Comparison across human populations reveals that industrialized lifestyles are associated with higher HGT rates and that the functions of HGTs are related to the level of host industrialization. Our results suggest that gut bacteria continuously acquire new functionality based on host lifestyle and that high rates of HGT may be a recent development in human history linked to industrialization. en
dc.format.extent 33
dc.language.iso eng
dc.relation.ispartof Cell
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject GUT MICROBIOTA
dc.subject GENOME
dc.subject EVOLUTION
dc.subject BACTERIA
dc.subject INFLAMMATION
dc.subject ANNOTATION
dc.subject MECHANISMS
dc.subject ALIGNMENT
dc.subject RESOURCE
dc.subject REVEALS
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title Elevated rates of horizontal gene transfer in the industrialized human microbiome en
dc.type Article
dc.contributor.organization Centre of Excellence in Metapopulation Research
dc.contributor.organization Helsinki Institute of Sustainability Science (HELSUS)
dc.contributor.organization Veijo Kaitala / Principal Investigator
dc.contributor.organization Faculty of Biological and Environmental Sciences
dc.contributor.organization Neuroscience Center
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.cell.2021.02.052
dc.relation.issn 0092-8674
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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