The Multifaceted Roles of KCC2 in Cortical Development

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http://hdl.handle.net/10138/330249

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Virtanen , M A , Uvarov , P , Mavrovic , M , Poncer , J C & Kaila , K 2021 , ' The Multifaceted Roles of KCC2 in Cortical Development ' , Trends in Neurosciences , vol. 44 , no. 5 , pp. 378-392 . https://doi.org/10.1016/j.tins.2021.01.004

Title: The Multifaceted Roles of KCC2 in Cortical Development
Author: Virtanen, Mari A; Uvarov, Pavel; Mavrovic, Martina; Poncer, Jean Christophe; Kaila, Kai
Contributor: University of Helsinki, Molecular and Integrative Biosciences Research Programme
University of Helsinki, Neuroscience Center
University of Helsinki, Laboratory of Neurobiology
University of Helsinki, Molecular and Integrative Biosciences Research Programme
Date: 2021-05
Language: eng
Number of pages: 15
Belongs to series: Trends in Neurosciences
ISSN: 0166-2236
URI: http://hdl.handle.net/10138/330249
Abstract: KCC2, best known as the neuron-specific chloride-extruder that sets the strength and polarity of GABAergic currents during neuronal maturation, isa multifunctional molecule that can regulate cytoskeletal dynamics via its C-terminal domain (CTD). We describe the molecular and cellular mechanisms involved in the multiple functions of KCC2 and its splice variants, ranging from developmental apoptosis and the control of early network events to the formation and plasticity of cortical dendritic spines. The versatility of KCC2 actions at the cellular and subcellular levels is also evident in mature neurons during plasticity, disease, and aging. Thus, KCC2 has emerged as one of the most important molecules that shape the overall neuronal phenotype.
Subject: 3112 Neurosciences
K-CL COTRANSPORTER
CATION-CHLORIDE COTRANSPORTERS
CRYO-EM STRUCTURES
NEURONAL-ACTIVITY
DENDRITIC SPINES
ION-TRANSPORT
SPAK/OSR1 KINASES
ACTIN DYNAMICS
GABA ACTIONS
RECEPTOR
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