Microneedles for painless transdermal immunotherapeutic applications

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dc.contributor.author Amani, Hamed
dc.contributor.author Shahbazi, Mohammad-Ali
dc.contributor.author D'Amico, Carmine
dc.contributor.author Fontana, Flavia
dc.contributor.author Abbaszadeh, Samin
dc.contributor.author Santos, Hélder A.
dc.date.accessioned 2021-05-25T09:57:01Z
dc.date.available 2021-05-25T09:57:01Z
dc.date.issued 2021-02-10
dc.identifier.citation Amani , H , Shahbazi , M-A , D'Amico , C , Fontana , F , Abbaszadeh , S & Santos , H A 2021 , ' Microneedles for painless transdermal immunotherapeutic applications ' , Journal of Controlled Release , vol. 330 , pp. 185-217 . https://doi.org/10.1016/j.jconrel.2020.12.019
dc.identifier.other PURE: 157435380
dc.identifier.other PURE UUID: 00132db9-ba4a-49b8-9a88-a6f04948f54f
dc.identifier.other WOS: 000626459100015
dc.identifier.other ORCID: /0000-0001-9112-6917/work/94444065
dc.identifier.other ORCID: /0000-0001-7850-6309/work/103469450
dc.identifier.uri http://hdl.handle.net/10138/330254
dc.description.abstract Immunotherapy has recently garnered plenty of attention to improve the clinical outcomes in the treatment of various diseases. However, owing to the dynamic nature of the immune system, this approach has often been challenged by concerns regarding the lack of adequate long-term responses in patients. The development of microneedles (MNs) has resulted in the improvement and expansion of immuno-reprogramming strategies due to the housing of high accumulation of dendritic cells, macrophages, lymphocytes, and mast cells in the dermis layer of the skin. In addition, MNs possess many outstanding properties, such as the ability for the painless traverse of the stratum corneum, minimal invasiveness, facile fabrication, excellent biocompatibility, convenient administration, and bypassing the first pass metabolism that allows direct translocation of therapeutics into the systematic circulation. These advantages make MNs excellent candidates for the delivery of immunological biomolecules to the dermal antigen-presenting cells in the skin with the aim of vaccinating or treating different diseases, such as cancer and autoimmune disorders, with minimal invasiveness and side effects. This review discusses the recent advances in engineered MNs and tackles limitations relevant to traditional immunotherapy of various hard-to-treat diseases. en
dc.format.extent 33
dc.language.iso eng
dc.relation.ispartof Journal of Controlled Release
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Allergy
dc.subject Autoimmune disease
dc.subject Cancer therapy
dc.subject Infection
dc.subject Microneedles
dc.subject Vaccination
dc.subject 317 Pharmacy
dc.title Microneedles for painless transdermal immunotherapeutic applications en
dc.type Article
dc.contributor.organization Nanomedicines and Biomedical Engineering
dc.contributor.organization Division of Pharmaceutical Chemistry and Technology
dc.contributor.organization Drug Research Program
dc.contributor.organization Helsinki One Health (HOH)
dc.contributor.organization Divisions of Faculty of Pharmacy
dc.contributor.organization Helsinki Institute of Life Science HiLIFE
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.jconrel.2020.12.019
dc.relation.issn 1873-4995
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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