Three-Dimensional Presentation of Tumor Histopathology : A Model Using Tongue Squamous Cell Carcinoma

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http://hdl.handle.net/10138/330270

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Koivuholma , A , Aro , K , Mäkitie , A , Salmi , M , Mirtti , T , Hagström , J & Atula , T 2021 , ' Three-Dimensional Presentation of Tumor Histopathology : A Model Using Tongue Squamous Cell Carcinoma ' , Diagnostics , vol. 11 , no. 1 , 109 . https://doi.org/10.3390/diagnostics11010109

Title: Three-Dimensional Presentation of Tumor Histopathology : A Model Using Tongue Squamous Cell Carcinoma
Author: Koivuholma, Anne; Aro, Katri; Mäkitie, Antti; Salmi, Mika; Mirtti, Tuomas; Hagström, Jaana; Atula, Timo
Contributor: University of Helsinki, Korva-, nenä- ja kurkkutautien klinikka
University of Helsinki, HUS Head and Neck Center
University of Helsinki, HUS Head and Neck Center
University of Helsinki, Research Program in Systems Oncology
University of Helsinki, HUS Head and Neck Center
University of Helsinki, University of Helsinki
Date: 2021-01
Language: eng
Number of pages: 9
Belongs to series: Diagnostics
ISSN: 2075-4418
URI: http://hdl.handle.net/10138/330270
Abstract: Medical imaging often presents objects in three-dimensional (3D) form to provide better visual understanding. In contrast, histopathology is typically presented as two-dimensional (2D). Our objective was to present the tumor dimensions in 3D by creating a 3D digital model of it and so demonstrate the location of the tumor and the histological slices within the surgical soft tissue resection specimen. We developed a novel method for modeling a tongue squamous cell carcinoma using commonly available instruments. We established our 3D-modeling method by recognizing and solving challenges that concern the selection of the direction of histological slices. Additional steps to standard handling included scanning the specimen prior to grossing and modeling the carcinoma, which required only a table scanner and modeling software. We present challenges and their solutions in modeling the resection specimen and its histological slices. We introduce a finished 3D model of a soft tissue resection specimen and the actual tumor as well as its histopathological grossing sites in 3D digital and printed form. Our novel method provides steps to create a digital model of soft tissue resection specimen and the tumor within. To our knowledge, this is the first attempt to present histopathological margins of a tongue tumor in 3D form, whereas previously, only 2D has been available. The creation of the 3D model does not call for predetermined grossing directions for the pathologist. In addition, it provides a crucial initiative to enhance oncological management. The method allows a better visual understanding of tumor margins, topography, and orientation. It thus provides a tool for an improved postoperative assessment and aids, for example, in the discussion of the need for additional surgery and adjuvant therapy.
Subject: histopathology
three-dimensional reconstruction
computer-aided design
cancer
tongue
3125 Otorhinolaryngology, ophthalmology
3122 Cancers
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