Desulfovibrio Bacteria Are Associated With Parkinson's Disease

Show full item record



Permalink

http://hdl.handle.net/10138/330350

Citation

Murros , K E , Huynh , A V , Takala , T M & Saris , P E J 2021 , ' Desulfovibrio Bacteria Are Associated With Parkinson's Disease ' , Frontiers in Cellular and Infection Microbiology , vol. 11 , 652617 . https://doi.org/10.3389/fcimb.2021.652617

Title: Desulfovibrio Bacteria Are Associated With Parkinson's Disease
Author: Murros, Kari E.; Huynh, Anh Vy; Takala, Timo M.; Saris, Per E. J.
Contributor organization: Department of Microbiology
Antimicrobials, probiotics and fermented food
Date: 2021-05-03
Language: eng
Number of pages: 10
Belongs to series: Frontiers in Cellular and Infection Microbiology
ISSN: 2235-2988
DOI: https://doi.org/10.3389/fcimb.2021.652617
URI: http://hdl.handle.net/10138/330350
Abstract: Parkinson's disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein alpha-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson's disease (PD) remains unknown. Intestinal dysfunction and changes in the gut microbiota, common symptoms of PD, are evidently linked to the pathogenesis of PD. Although a multitude of studies have investigated microbial etiologies of PD, the microbial role in disease progression remains unclear. Here, we show that Gram-negative sulfate-reducing bacteria of the genus Desulfovibrio may play a potential role in the development of PD. Conventional and quantitative real-time PCR analysis of feces from twenty PD patients and twenty healthy controls revealed that all PD patients harbored Desulfovibrio bacteria in their gut microbiota and these bacteria were present at higher levels in PD patients than in healthy controls. Additionally, the concentration of Desulfovibrio species correlated with the severity of PD. Desulfovibrio bacteria produce hydrogen sulfide and lipopolysaccharide, and several strains synthesize magnetite, all of which likely induce the oligomerization and aggregation of alpha-synuclein protein. The substances originating from Desulfovibrio bacteria likely take part in pathogenesis of PD. These findings may open new avenues for the treatment of PD and the identification of people at risk for developing PD.
Subject: hydrogen sulfide
magnetite
alpha-synuclein (&#945
-Syn)
gut Desulfovibrio bacteria
Parkinson&#8217
s disease (PD)
SULFATE-REDUCING BACTERIA
ALTERED GUT MICROBIOME
ALPHA-SYNUCLEIN
HYDROGEN-SULFIDE
AKKERMANSIA-MUCINIPHILA
SULFUR METABOLISM
ENERGY-METABOLISM
A-SYNUCLEIN
IRON
HEALTHY
1182 Biochemistry, cell and molecular biology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


Files in this item

Total number of downloads: Loading...

Files Size Format View
fcimb_11_652617.pdf 379.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record