Time is of the essence : Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine

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dc.contributor.author Kohtala, S.
dc.contributor.author Alitalo, O.
dc.contributor.author Rosenholm, M.
dc.contributor.author Rozov, S.
dc.contributor.author Rantamäki, T.
dc.date.accessioned 2021-05-31T09:03:02Z
dc.date.available 2021-05-31T09:03:02Z
dc.date.issued 2021-05
dc.identifier.citation Kohtala , S , Alitalo , O , Rosenholm , M , Rozov , S & Rantamäki , T 2021 , ' Time is of the essence : Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine ' , Pharmacology & Therapeutics , vol. 221 , 107741 , pp. 107741 . https://doi.org/10.1016/j.pharmthera.2020.107741
dc.identifier.other PURE: 162755215
dc.identifier.other PURE UUID: 2c40b462-e309-44eb-a440-d2a4d70ba1b6
dc.identifier.other Bibtex: KOHTALA2021107741
dc.identifier.other WOS: 000644068100012
dc.identifier.other ORCID: /0000-0002-0052-1434/work/94751210
dc.identifier.other ORCID: /0000-0001-7446-0673/work/94752696
dc.identifier.other ORCID: /0000-0001-9249-085X/work/94752913
dc.identifier.other ORCID: /0000-0002-5437-8282/work/94753168
dc.identifier.uri http://hdl.handle.net/10138/330390
dc.description.abstract Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clinical treatments has been slow. This translational gap is partially explained by a lack of understanding of the function of time and circadian timing in the complex neurobiology around ketamine. Indeed, the acute pharmacological effects of a single ketamine treatment last for only a few hours, whereas the antidepressant effects peak at around 24 hours and are sustained for the following few days. Numerous studies have investigated the acute and long-lasting neurobiological changes induced by ketamine; however, the most dramatic and fundamental change that the brain undergoes each day is rarely taken into consideration. Here, we explore the link between sleep and circadian regulation and rapid-acting antidepressant effects and summarize how diverse phenomena associated with ketamine’s antidepressant actions – such as cortical excitation, synaptogenesis, and involved molecular determinants – are intimately connected with the neurobiology of wake, sleep, and circadian rhythms. We review several recently proposed hypotheses about rapid antidepressant actions, which focus on sleep or circadian regulation, and discuss their implications for ongoing research. Considering these aspects may be the last piece of the puzzle necessary to gain a more comprehensive understanding of the effects of rapid-acting antidepressants on the brain. fi
dc.description.abstract Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clinical treatments has been slow. This translational gap is partially explained by a lack of understanding of the function of time and circadian timing in the complex neurobiology around ketamine. Indeed, the acute pharmacological effects of a single ketamine treatment last for only a few hours, whereas the antidepressant effects peak at around 24 hours and are sustained for the following few days. Numerous studies have investigated the acute and long-lasting neurobiological changes induced by ketamine; however, the most dramatic and fundamental change that the brain undergoes each day is rarely taken into consideration. Here, we explore the link between sleep and circadian regulation and rapid -acting antidepressant effects and summarize how diverse phenomena associated with ketamine's antidepressant actions - such as cortical excitation, synaptogenesis, and involved molecular determinants - are intimately connected with the neurobiology of wake, sleep, and circadian rhythms. We review several recently proposed hypotheses about rapid antidepressant actions, which focus on sleep or circadian regulation, and discuss their implications for ongoing research. Considering these aspects may be the last piece of the puzzle necessary to gain a more comprehensive understanding of the effects of rapid-acting antidepressants on the brain. (c) 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/). en
dc.format.extent 17
dc.language.iso eng
dc.relation.ispartof Pharmacology & Therapeutics
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Sleep
dc.subject Circadian
dc.subject Plasticity
dc.subject Depression
dc.subject Rapid-acting antidepressant
dc.subject Slow-wave sleep
dc.subject GLYCOGEN-SYNTHASE KINASE-3
dc.subject RESISTANT MAJOR DEPRESSION
dc.subject LONG-TERM POTENTIATION
dc.subject CLOCK GENE-EXPRESSION
dc.subject BRIGHT LIGHT THERAPY
dc.subject BLOOD-BRAIN-BARRIER
dc.subject SLOW-WAVE ACTIVITY
dc.subject SUPRACHIASMATIC NUCLEUS
dc.subject NEUROTROPHIC FACTOR
dc.subject PREFRONTAL CORTEX
dc.subject 317 Pharmacy
dc.subject 3112 Neurosciences
dc.title Time is of the essence : Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine en
dc.type Review Article
dc.contributor.organization Division of Pharmacology and Pharmacotherapy
dc.contributor.organization Laboratory of Neurotherapeutics
dc.contributor.organization Drug Research Program
dc.contributor.organization SLEEPWELL Research Program
dc.contributor.organization Medicum
dc.contributor.organization INDIVIDRUG - Individualized Drug Therapy
dc.contributor.organization Doctoral Programme Brain & Mind
dc.contributor.organization Divisions of Faculty of Pharmacy
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.pharmthera.2020.107741
dc.relation.issn 0163-7258
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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