An organic-inorganic hybrid scaffold with honeycomb-like structures enabled by one-step self-assembly-driven electrospinning

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Ding , Y , Li , W , W. Schubert , D , R. Boccaccini , A , A. Roether , J & Santos , H A 2021 , ' An organic-inorganic hybrid scaffold with honeycomb-like structures enabled by one-step self-assembly-driven electrospinning ' , Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems , vol. 124 , 112079 . https://doi.org/10.1016/j.msec.2021.112079

Title: An organic-inorganic hybrid scaffold with honeycomb-like structures enabled by one-step self-assembly-driven electrospinning
Author: Ding, Yaping; Li, Wei; W. Schubert, Dirk; R. Boccaccini, Aldo; A. Roether, Judith; Santos, Hélder A.
Contributor: University of Helsinki, Divisions of Faculty of Pharmacy
University of Helsinki, Drug Research Program
University of Helsinki, Helsinki One Health (HOH)
Date: 2021-05
Language: eng
Number of pages: 8
Belongs to series: Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems
ISSN: 0928-4931
URI: http://hdl.handle.net/10138/330391
Abstract: Electrospun organic/inorganic hybrid scaffolds have been appealing in tissue regeneration owing to the integrated physiochemical and biological performances. However, the conventional electrospun scaffolds with non-woven structures usually failed to enable deep cell infiltration due to the densely stacked layers among the fibers. Herein, through self-assembly-driven electrospinning, a polyhydroxybutyrate/poly(ε-caprolactone)/58S sol-gel bioactive glass (PHB/PCL/58S) hybrid scaffold with honeycomb-like structures was prepared by manipulating the solution composition and concentration during a one-step electrospinning process. Here, the mechanisms enabling the formation of self-assembled honeycomb-like structures were investigated through comparative studies using Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) between PHB/PCL/58S and PHB/PCL/sol-gel silica systems. The obtained honeycomb-like structure was built up from nanofibers with an average diameter of 370 nm and showed a bimodal distribution of pores: large polygonal pores up to hundreds of micrometers within the honeycomb-cells and irregular pores among the nanofibers ranging around few micrometers. The cell-materials interactions were further studied by culturing MG-63 osteoblast-like cells for 7 days. Cell viability, cell morphology and cell infiltration were comparatively investigated as well. While cells merely proliferated on the surface of non-woven structures, MG-63 cells showed extensive proliferation and deep infiltration up to 100~200 μm into the honeycomb-like structure. Moreover, the cellular spatial organization was readily regulated by the honeycomb-like pattern as well. Overall, the newly obtained hybrid scaffold may integrate the enhanced osteogenicity originating from the bioactive components, and the improved cell-material interactions brought by the honeycomb-like structure, making the new scaffold a promising candidate for tissue regeneration.
Subject: 317 Pharmacy
318 Medical biotechnology
221 Nano-technology
Organic-inorganic hybrid scaffolds
Electrospinning
Self-assembly
Honeycomb-like architecture
TISSUE
NANOFIBERS
NANOCOMPOSITES
FABRICATION
GEOMETRY
TCP
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