Morphological Heterogeneity of the Endoplasmic Reticulum within Neurons and Its Implications in Neurodegeneration

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Sree , S , Parkkinen , I , Their , A , Airavaara , M & Jokitalo , E 2021 , ' Morphological Heterogeneity of the Endoplasmic Reticulum within Neurons and Its Implications in Neurodegeneration ' , Cells , vol. 10 , no. 5 , 970 . https://doi.org/10.3390/cells10050970

Title: Morphological Heterogeneity of the Endoplasmic Reticulum within Neurons and Its Implications in Neurodegeneration
Author: Sree, Sreesha; Parkkinen, Ilmari; Their, Anna; Airavaara, Mikko; Jokitalo, Eija
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Division of Pharmacology and Pharmacotherapy
University of Helsinki, Neuroscience Center
University of Helsinki, Drug Research Program
University of Helsinki, Institute of Biotechnology
Date: 2021-05
Language: eng
Number of pages: 24
Belongs to series: Cells
ISSN: 2073-4409
URI: http://hdl.handle.net/10138/330554
Abstract: The endoplasmic reticulum (ER) is a multipurpose organelle comprising dynamic structural subdomains, such as ER sheets and tubules, serving to maintain protein, calcium, and lipid homeostasis. In neurons, the single ER is compartmentalized with a careful segregation of the structural subdomains in somatic and neurite (axodendritic) regions. The distribution and arrangement of these ER subdomains varies between different neuronal types. Mutations in ER membrane shaping proteins and morphological changes in the ER are associated with various neurodegenerative diseases implying significance of ER morphology in maintaining neuronal integrity. Specific neurons, such as the highly arborized dopaminergic neurons, are prone to stress and neurodegeneration. Differences in morphology and functionality of ER between the neurons may account for their varied sensitivity to stress and neurodegenerative changes. In this review, we explore the neuronal ER and discuss its distinct morphological attributes and specific functions. We hypothesize that morphological heterogeneity of the ER in neurons is an important factor that accounts for their selective susceptibility to neurodegeneration.
Subject: neuronal endoplasmic reticulum
neurodegeneration
dopaminergic neurons
endoplasmic reticulum subdomains
sporadic neurodegeneration
HEREDITARY SPASTIC PARAPLEGIA
UNFOLDED PROTEIN RESPONSE
TO-TUBULE TRANSFORMATION
MEMBRANE CONTACT SITES
C-BOUTON INPUTS
ALPHA-SYNUCLEIN
DENDRITIC SPINES
PARKINSONS-DISEASE
ELECTRON-MICROSCOPY
ENDOMEMBRANE SYSTEM
1182 Biochemistry, cell and molecular biology
3112 Neurosciences
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