Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children

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Maleta , K , Fan , Y-M , Luoma , J , Ashorn , U , Bendabenda , J , Dewey , K G , Hyöty , H , Knip , M , Kortekangas , E , Lehto , K-M , Matchado , A , Nkhoma , M , Nurminen , N , Parkkila , S , Purmonen , S , Veijola , R , Oikarinen , S & Ashorn , P 2021 , ' Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children ' , American Journal of Clinical Nutrition , vol. 113 , no. 2 , pp. 380-390 . https://doi.org/10.1093/ajcn/nqaa327

Title: Infections and systemic inflammation are associated with lower plasma concentration of insulin-like growth factor I among Malawian children
Author: Maleta, Kenneth; Fan, Yue-Mei; Luoma, Juho; Ashorn, Ulla; Bendabenda, Jaden; Dewey, Kathryn G.; Hyöty, Heikki; Knip, Mikael; Kortekangas, Emma; Lehto, Kirsi-Maarit; Matchado, Andrew; Nkhoma, Minyanga; Nurminen, Noora; Parkkila, Seppo; Purmonen, Sami; Veijola, Riitta; Oikarinen, Sami; Ashorn, Per
Other contributor: University of Helsinki, HUS Children and Adolescents





Date: 2021-02
Language: eng
Number of pages: 11
Belongs to series: American Journal of Clinical Nutrition
ISSN: 0002-9165
DOI: https://doi.org/10.1093/ajcn/nqaa327
URI: http://hdl.handle.net/10138/330558
Abstract: Background: Insulin-like growth factor I (IGF-I) is the most important hormonal promoter of linear growth in infants and young children. Objectives: The objectives of this study were to compare plasma IGF-I concentration in a low- compared with a high-income country and characterize biological pathways leading to reduced IGF-I concentration in children in a low-income setting. Methods: We analyzed plasma IGF-I concentration from 716 Malawian and 80 Finnish children at 6-36 mo of age. In the Malawian children, we studied the association between IGF-I concentration and their environmental exposures; nutritional status; systemic and intestinal inflammation; malaria parasitemia and viral, bacterial, and parasitic enteric infections; as well as growth at 18 mo of age. We then conducted a pathway analysis to identify direct and indirect associations between these predictors and IGF-I concentration. Results: The mean IGF-I concentrations were similar in Malawi and Finland among 6-mo-old infants. At age 18 mo. the mean +/- SD concentration was almost double among the Finns compared with the Malawians [24.2 +/- 11.3 compared with 12.5 +/- 7.7 ng/mL., age- and sex-adjusted difference in mean (95% CI): 11.8 (9.9. 13.7) ng/mL; P <0.01]. Among 18-mo-old Malawians, plasma IGF-I concentration was inversely associated with systemic inflammation, malaria parasitemia, and intestinal Shigella. Campylobacter, and enterovirus infection and positively associated with the children's weight-for-length z score (WLZ), female sex, maternal height, mother's education, and dry season. Seasonally, mean plasma IGF-I concentration was highest in June and July and lowest in December and January, coinciding with changes in children's length gain and preceded by similar to 2 mo by the changes in their WLZ. Conclusions: The mean plasma IGF-I concentrations are similar in Malawi and Finland among 6-mo-old infants. Thereafter, mean concentrations rise markedly in Finland but not in Malawi. Systemic inflammation and clinically nonapparent infections are strongly associated with lower plasma IGF-I concentrations in Malawi through direct and indirect pathways.
Subject: childhood growth faltering
stunting
infection
hormonal regulation
pathway analysis
systemic inflammation
LINEAR GROWTH
IGF-I
RURAL MALAWI
CHILDHOOD
DIARRHEA
NUTRITION
AGE
GH
CONSEQUENCES
DISEASE
3123 Gynaecology and paediatrics
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